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将抗疟药物tafenoquine 重新用于对抗耐甲氧西林金黄色葡萄球菌（MRSA）。

Repurposing of the antimalarial agent tafenoquine to combat MRSA.

机构信息

Department of Laboratory Medicine, The Third Xiangya Hospital of Central South University, Changsha, China.

Department of Laboratory Medicine, The Affiliated Changsha Hospital of Xiangya School of Medicine (The First Hospital of Changsha), Central South University, Changsha, China.

出版信息

mSystems. 2023 Dec 21;8(6):e0102623. doi: 10.1128/msystems.01026-23. Epub 2023 Dec 4.

DOI:10.1128/msystems.01026-23
PMID:38047647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10734505/
Abstract

This study represents the first investigation into the antimicrobial effect of TAF against and its potential mechanisms. Our data highlighted the effects of TAF against MRSA planktonic cells, biofilms, and persister cells, which is conducive to broadening the application of TAF. Through mechanistic studies, we revealed that TAF targets bacterial cell membranes. In addition, the experiments in mice demonstrated the safety and antimicrobial efficacy of TAF, suggesting that TAF could be a potential antibacterial drug candidate for the treatment of infections caused by multiple drug-resistant .

摘要

这项研究首次调查了 TAF 对 和其潜在机制的抗菌作用。我们的数据强调了 TAF 对 MRSA 浮游细胞、生物膜和持久细胞的作用，这有利于拓宽 TAF 的应用。通过机制研究，我们揭示了 TAF 靶向细菌细胞膜。此外，在小鼠中的 实验证明了 TAF 的安全性和抗菌疗效，表明 TAF 可能成为治疗多重耐药 引起的感染的潜在抗菌药物候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/038d/10734505/3512bb8398e1/msystems.01026-23.f007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/038d/10734505/3a148e44dc1f/msystems.01026-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/038d/10734505/3662c085ec9c/msystems.01026-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/038d/10734505/c4656d609163/msystems.01026-23.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/038d/10734505/72fb8298162d/msystems.01026-23.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/038d/10734505/bb7ef35374f5/msystems.01026-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/038d/10734505/7412b3fbc3d0/msystems.01026-23.f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/038d/10734505/3512bb8398e1/msystems.01026-23.f007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/038d/10734505/3a148e44dc1f/msystems.01026-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/038d/10734505/3662c085ec9c/msystems.01026-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/038d/10734505/c4656d609163/msystems.01026-23.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/038d/10734505/72fb8298162d/msystems.01026-23.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/038d/10734505/bb7ef35374f5/msystems.01026-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/038d/10734505/7412b3fbc3d0/msystems.01026-23.f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/038d/10734505/3512bb8398e1/msystems.01026-23.f007.jpg

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