木层孔菌素A - C，从短柄木层孔菌YSJ - 5中分离得到的三种新型异海松烷型二萜糖苷。
Xylarcurcosides A-C, three novel isopimarane-type diterpene glycosides from Xylaria curta YSJ-5.
作者信息
Wei Shanshan, Chen Chen, Lai Jiaying, Zhang Yanjiang, Nong Xinmiao, Duan Fangfang, Wu Ping, Wang Sasa, Tan Haibo
机构信息
Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, China.
出版信息
Carbohydr Res. 2024 Jan;535:108987. doi: 10.1016/j.carres.2023.108987. Epub 2023 Nov 23.
Three previously undescribed isopimarane-type diterpene glycosides named as xylarcurcosides A-C (1-3) along with two known ones 16-α-d-mannopyranosyloxyisopimar-7-en-19-oic acid (4) and hypoxylonoid A (5) were successfully isolated from an ethyl acetate extract of the endophytic fungus Xylaria curta YSJ-5 growing in leaves of Alpinia zerumbet. The spectroscopic methods, electronic circular dichroism (ECD) calculations, and X-ray diffraction experiments were conducted to identify their absolute chemical structures. All these compounds were tested for in vitro cytotoxic, anti-inflammatory, α-glucosidase inhibitory, and antibacterial activities. As a result, these novel compounds demonstrated no obvious cytotoxic and antibacterial activity.
从生长在艳山姜叶片上的内生真菌短节炭角菌YSJ-5的乙酸乙酯提取物中，成功分离出三种此前未被描述的异海松烷型二萜糖苷，命名为木生炭角菌素A-C（1-3），以及两种已知化合物16-α-D-甘露吡喃糖氧基异海松-7-烯-19-酸（4）和炭角菌素A（5）。通过光谱方法、电子圆二色性（ECD）计算和X射线衍射实验确定了它们的绝对化学结构。对所有这些化合物进行了体外细胞毒性、抗炎、α-葡萄糖苷酶抑制和抗菌活性测试。结果，这些新化合物没有表现出明显的细胞毒性和抗菌活性。
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