Rahi A H
Br J Ophthalmol. 1979 May;63(5):283-92. doi: 10.1136/bjo.63.5.283.
This review article discusses the evolution and function of the histocompatibility system, the nature of the HLA antigens and their classification, the phenomenon of linkage disequilibrium, and the mechanisms of HLA and disease susceptibility. The reported associations between HLA antigens and various eye diseases are analysed and their significance is discussed. Problems in designing studies on HLA and disease associations are highlighted and suitable statistical procedures for the analysis of the results are outlined.
这篇综述文章讨论了组织相容性系统的演变和功能、HLA抗原的性质及其分类、连锁不平衡现象,以及HLA与疾病易感性的机制。分析了所报道的HLA抗原与各种眼部疾病之间的关联,并讨论了其意义。强调了设计HLA与疾病关联研究时存在的问题,并概述了分析结果的合适统计程序。