程序性细胞死亡蛋白1配体1的表达机制及其在间充质干细胞免疫调节能力中的作用。
The expression mechanism of programmed cell death 1 ligand 1 and its role in immunomodulatory ability of mesenchymal stem cells.
作者信息
Chen Zhuo, Yao Meng-Wei, Ao Xiang, Gong Qing-Jia, Yang Yi, Liu Jin-Xia, Lian Qi-Zhou, Xu Xiang, Zuo Ling-Jing
机构信息
Department of Stem Cell & Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University, Chongqing, 400042, China; College of Basic Medical Sciences, Army Medical University, Chongqing, 400038, China.
Department of Stem Cell & Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University, Chongqing, 400042, China.
出版信息
Chin J Traumatol. 2024 Jan;27(1):1-10. doi: 10.1016/j.cjtee.2023.11.003. Epub 2023 Nov 23.
Programmed cell death 1 ligand 1 (PD-L1) is an important immunosuppressive molecule, which inhibits the function of T cells and other immune cells by binding to the receptor programmed cell death-1. The PD-L1 expression disorder plays an important role in the occurrence, development, and treatment of sepsis or other inflammatory diseases, and has become an important target for the treatment of these diseases. Mesenchymal stem cells (MSCs) are a kind of pluripotent stem cells with multiple differentiation potential. In recent years, MSCs have been found to have a strong immunosuppressive ability and are used to treat various inflammatory insults caused by hyperimmune diseases. Moreover, PD-L1 is deeply involved in the immunosuppressive events of MSCs and plays an important role in the treatment of various diseases. In this review, we will summarize the main regulatory mechanism of PD-L1 expression, and discuss various biological functions of PD-L1 in the immune regulation of MSCs.
程序性细胞死亡1配体1（PD-L1）是一种重要的免疫抑制分子，它通过与程序性细胞死亡受体1结合来抑制T细胞和其他免疫细胞的功能。PD-L1表达紊乱在脓毒症或其他炎症性疾病的发生、发展及治疗中起重要作用，已成为这些疾病治疗的重要靶点。间充质干细胞（MSCs）是一类具有多向分化潜能的多能干细胞。近年来，发现MSCs具有强大的免疫抑制能力，并被用于治疗由超免疫疾病引起的各种炎症损伤。此外，PD-L1深度参与MSCs的免疫抑制事件，并在各种疾病的治疗中发挥重要作用。在本综述中，我们将总结PD-L1表达的主要调控机制，并讨论PD-L1在MSCs免疫调节中的各种生物学功能。
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