小头畸形大鼠视网膜向外侧后核的异常投射。

An abnormal retinal projection to the lateral posterior nucleus in micrencephalic rats.

作者信息

Ashwell K

出版信息

Neurosci Lett. 1986 Dec 3;72(1):7-13. doi: 10.1016/0304-3940(86)90609-9.

Abstract

The retinofugal projections of albino rats made micrencephalic by prenatal exposure to the cytotoxic teratogen methylazoxymethanol acetate (MAM Ac) have been examined. The only abnormality noted was an increased projection to the lateral posterior nucleus of the thalamus in rats exposed to MAM Ac on embryonic day 15. The relatively normal retinofugal projections were surprising in view of the extensive damage induced by prenatal exposure to this drug.

摘要

对白化大鼠进行了研究，这些大鼠在产前接触细胞毒性致畸剂乙酸甲基偶氮甲醇（MAM Ac）后形成了小脑发育不全。唯一观察到的异常是在胚胎第15天接触MAM Ac的大鼠中，丘脑外侧后核的投射增加。鉴于产前接触这种药物会引起广泛损伤，相对正常的视网膜投射令人惊讶。