Division of Allergy and Clinical Immunology, Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA; Mary H. Weiser Food Allergy Center, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Mary H. Weiser Food Allergy Center, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA; Department of Dermatology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.
J Invest Dermatol. 2024 May;144(5):954-968. doi: 10.1016/j.jid.2023.10.019. Epub 2023 Dec 11.
Type 2 immune-mediated diseases give a clear answer to the issue of nature (genetics) versus nurture (environment). Both genetics and environment play vital complementary roles in the development of atopic dermatitis (AD). As a key component of the atopic march, AD demonstrates the interactive nature of genetic and environmental contributions to atopy. From sequence variants in the epithelial barrier gene encoding FLG to the hygiene hypothesis, AD combines a broad array of contributions into a single syndrome. This review will focus on the genetic contribution to AD and where genetics facilitates the elicitation or enhancement of AD pathogenesis.
2 型免疫介导性疾病明确回答了自然(遗传)与养育(环境)的问题。遗传和环境在特应性皮炎(AD)的发展中都起着至关重要的互补作用。作为特应性进程的关键组成部分,AD 表明遗传和环境对特应性的贡献具有相互作用的性质。从编码 FLG 的上皮屏障基因中的序列变异到卫生假说,AD 将广泛的贡献组合成一个单一的综合征。本综述将重点关注 AD 的遗传贡献,以及遗传如何促进或增强 AD 的发病机制。