Cell Polarity, Migration and Cancer Unit, Université de Paris, UMR3691 CNRS, Equipe Labellisée Ligue 2023, Institut Pasteur, Paris, France.
J Cell Biol. 2024 Jan 1;223(1). doi: 10.1083/jcb.202308069. Epub 2023 Dec 13.
Cell polarity, which consists of the morphological, structural, and functional organization of cells along a defined axis, is a feature of healthy cells and tissues. In contrast, abnormal polarity is a hallmark of cancer cells. At the molecular level, key evolutionarily conserved proteins that control polarity establishment and maintenance in various contexts are frequently altered in cancer, but the relevance of these molecular alterations in the oncogenic processes is not always clear. Here, we summarize the recent findings, shedding new light on the involvement of polarity players in cancer development, and discuss the possibility of harnessing cell polarity changes to better predict, diagnose, and cure cancers.
细胞极性是指细胞沿着特定轴呈现出的形态、结构和功能的组织，是健康细胞和组织的特征。相反，异常的极性是癌细胞的一个标志。在分子水平上，在各种情况下控制极性建立和维持的关键进化保守蛋白在癌症中经常发生改变，但这些分子改变在致癌过程中的相关性并不总是清楚。在这里，我们总结了最近的发现，揭示了极性蛋白在癌症发展中的作用，并探讨了利用细胞极性变化来更好地预测、诊断和治疗癌症的可能性。
