Department of Neurointervention and Neurological Intensive Care, Dalian Central Hospital Affiliated to Dalian University of Technology, Dalian City, Liaoning Province, China.
Department of Neurology, Dalian Central Hospital Affiliated to Dalian University of Technology, Dalian City, Liaoning Province, China.
Clin Appl Thromb Hemost. 2023 Jan-Dec;29:10760296231219707. doi: 10.1177/10760296231219707.
Early neurological deterioration after intravenous thrombolysis (IAT) leads to increased mortality and morbidity in patients with acute ischemic stroke (AIS). This study investigated the correlation between serum Cav-1 and NGB levels and END after IAT and explored their predictive values for poor prognosis of AIS. Totally 210 patients with AIS who underwent IAT within 4.5 h of onset were included and assigned into END group (n = 90) and Non-END group (n = 120). ELISA was used to detect serum Cav-1 and NGB levels before IAT in AIS patients. The prognosis of END patients after 3 months of treatment was evaluated using the modified Rankin Scale. Logistic multifactorial regression was used to analyze independent risk factors for END and poor prognosis after IAT. ROC curve was used to analyze the predictive effect of Cav-1 and NGB on END and poor prognosis after IAT. The area under the ROC curve was analyzed by MedCalc comparison. Compared with the Non-END group, serum Cav-1 was lower and NGB was higher in the END group. Cav-1 and NGB were independent risk factors for END after IAT. Cav-1 + NGB better predicted END after IAT than Cav-1 or NGB alone. Cav-1 and NGB were independent risk factors for END poor prognosis after IAT. Cav-1 combined with NGB better predicted poor prognosis of END after IAT than Cav-1 or NGB alone. Serum Cav-1 combined with NGB may assist in predicting the risk of END occurrence and poor prognosis after IAT in patients with AIS.
急性缺血性脑卒中（AIS）患者静脉溶栓（IAT）后早期神经功能恶化（END）可导致死亡率和发病率增加。本研究探讨了 IAT 后血清 Cav-1 和 NGB 水平与 END 的相关性，并探讨了它们对 AIS 不良预后的预测价值。共纳入 210 例发病 4.5 h 内接受 IAT 的 AIS 患者，分为 END 组（n=90）和非 END 组（n=120）。采用 ELISA 法检测 AIS 患者 IAT 前血清 Cav-1 和 NGB 水平。治疗 3 个月后采用改良 Rankin 量表评估 END 患者预后。采用多因素 logistic 回归分析 END 及 IAT 后不良预后的独立危险因素。ROC 曲线分析 Cav-1 和 NGB 对 IAT 后 END 及不良预后的预测效果。采用 MedCalc 比较分析 ROC 曲线下面积。与非 END 组比较，END 组血清 Cav-1 降低，NGB 升高。Cav-1 和 NGB 是 IAT 后 END 的独立危险因素。Cav-1+NGB 预测 IAT 后 END 优于 Cav-1 或 NGB 单独预测。Cav-1 和 NGB 是 IAT 后 END 不良预后的独立危险因素。Cav-1 联合 NGB 预测 IAT 后 END 不良预后优于 Cav-1 或 NGB 单独预测。血清 Cav-1 联合 NGB 可能有助于预测 AIS 患者 IAT 后 END 发生和不良预后的风险。
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