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Therapeutic targeting of the functionally elusive TAM receptor family.
Nat Rev Drug Discov. 2024 Mar;23(3):201-217. doi: 10.1038/s41573-023-00846-8. Epub 2023 Dec 13.
2
TAM family kinases as therapeutic targets at the interface of cancer and immunity.
Nat Rev Clin Oncol. 2023 Nov;20(11):755-779. doi: 10.1038/s41571-023-00813-7. Epub 2023 Sep 4.
3
TAM-ing T cells in the tumor microenvironment: implications for TAM receptor targeting.
Cancer Immunol Immunother. 2020 Feb;69(2):237-244. doi: 10.1007/s00262-019-02421-w. Epub 2019 Oct 29.
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Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression.
Mol Cancer Res. 2017 Jun;15(6):753-764. doi: 10.1158/1541-7786.MCR-16-0350. Epub 2017 Feb 9.
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Targeted degradation of MERTK and other TAM receptor paralogs by heterobifunctional targeted protein degraders.
Front Immunol. 2023 Jul 20;14:1135373. doi: 10.3389/fimmu.2023.1135373. eCollection 2023.
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TYRO3 as a molecular target for growth inhibition and apoptosis induction in bladder cancer.
Br J Cancer. 2019 Mar;120(5):555-564. doi: 10.1038/s41416-019-0397-6. Epub 2019 Feb 15.
10
Recent advances in TAM mechanisms in lung diseases.
J Transl Med. 2025 Apr 26;23(1):479. doi: 10.1186/s12967-025-06398-2.

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Inhibitory effect on endometrial cancer: Collagen type XII α1 chain.
Cytojournal. 2025 Mar 12;22:31. doi: 10.25259/Cytojournal_236_2024. eCollection 2025.
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STELLAR-305: phase II/III study of zanzalintinib plus pembrolizumab versus pembrolizumab alone in patients with HNSCC.
Future Oncol. 2025 May;21(11):1349-1356. doi: 10.1080/14796694.2025.2485015. Epub 2025 Apr 18.
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Proteolysis of TAM receptors in autoimmune diseases and cancer: what does it say to us?
Cell Death Dis. 2025 Mar 5;16(1):155. doi: 10.1038/s41419-025-07480-9.
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MERTK inhibition improves therapeutic efficacy of immune checkpoint inhibitors in hepatocellular carcinoma.
Oncoimmunology. 2025 Dec;14(1):2473165. doi: 10.1080/2162402X.2025.2473165. Epub 2025 Mar 3.
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AXL signaling in cancer: from molecular insights to targeted therapies.
Signal Transduct Target Ther. 2025 Feb 10;10(1):37. doi: 10.1038/s41392-024-02121-7.
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Targeting AXL Inhibits the Growth and Metastasis of Prostate Cancer in Bone.
Clin Cancer Res. 2025 Apr 1;31(7):1346-1358. doi: 10.1158/1078-0432.CCR-24-3028.

本文引用的文献

1
Tissue-specific modifier alleles determine loss-of-function traits.
Elife. 2022 Aug 15;11:e80530. doi: 10.7554/eLife.80530.
4
AXL receptor is required for Zika virus strain MR-766 infection in human glioblastoma cell lines.
Mol Ther Oncolytics. 2021 Nov 11;23:447-457. doi: 10.1016/j.omto.2021.11.001. eCollection 2021 Dec 17.
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Inhibition of AXL and VEGF-A Has Improved Therapeutic Efficacy in Uterine Serous Cancer.
Cancers (Basel). 2021 Nov 23;13(23):5877. doi: 10.3390/cancers13235877.
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Targeting MERTK and AXL in Mutant Non-Small Cell Lung Cancer.
Cancers (Basel). 2021 Nov 11;13(22):5639. doi: 10.3390/cancers13225639.
7
Phosphatidylserine receptors enhance SARS-CoV-2 infection.
PLoS Pathog. 2021 Nov 19;17(11):e1009743. doi: 10.1371/journal.ppat.1009743. eCollection 2021 Nov.

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