Health Science Center, Ningbo University, Ningbo, 315211, Zhejiang, People's Republic of China.
Ningbo Clinical Research Center for Urological Disease, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, Zhejiang, People's Republic of China.
J Nanobiotechnology. 2023 Dec 14;21(1):480. doi: 10.1186/s12951-023-02219-0.
Current diagnostic tools for prostate cancer (PCa) diagnosis and risk stratification are insufficient. The hidden onset and poor efficacy of traditional therapies against metastatic PCa make this disease a heavy burden in global men's health. Prostate cancer-derived extracellular vesicles (PCDEVs) have garnered attention in recent years due to their important role in communications in tumor microenvironment. Recent advancements have demonstrated PCDEVs proteins play an important role in PCa invasion, progression, metastasis, therapeutic resistance, and immune escape. In this review, we briefly discuss the applications of sEV proteins in PCa diagnosis and prognosis in liquid biopsy, focus on the roles of the PCa-derived small EVs (sEVs) proteins in tumor microenvironment associated with cancer progression, and explore the therapeutic potential of sEV proteins applied for future metastatic PCa therapy.
目前用于前列腺癌（PCa）诊断和风险分层的诊断工具还不够完善。传统治疗转移性 PCa 的方法隐藏发病且效果不佳，使这种疾病成为全球男性健康的沉重负担。由于其在肿瘤微环境中的通讯中起着重要作用，近年来前列腺癌衍生的细胞外囊泡（PCDEVs）引起了人们的关注。最近的进展表明，PCDEVs 蛋白在 PCa 的侵袭、进展、转移、治疗耐药性和免疫逃逸中发挥着重要作用。在这篇综述中，我们简要讨论了 sEV 蛋白在液体活检中用于 PCa 诊断和预后的应用，重点介绍了与癌症进展相关的肿瘤微环境中 PCa 衍生的小 EVs（sEVs）蛋白的作用，并探讨了 sEV 蛋白在未来转移性 PCa 治疗中的治疗潜力。
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