首例 Apiotrichum mycotoxinivorans 从人脑脊液中分离的报告。
The first report of Apiotrichum mycotoxinivorans isolation from human cerebrospinal fluid.
机构信息
Maternal and Child Health Development Research Center, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, 250014, China.
Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
出版信息
Eur J Clin Microbiol Infect Dis. 2024 Mar;43(3):597-604. doi: 10.1007/s10096-023-04736-0. Epub 2023 Dec 16.
Fungal infections due to Apiotrichum mycotoxinivorans are clinically rare. Here, we report a case of invasive blood and cerebrospinal fluid infection by Apiotrichum mycotoxinivorans in a girl with B-cell acute lymphoblastic leukemia. This is the first report of the isolation of Apiotrichum mycotoxinivorans from human cerebrospinal fluid. MRI features of meningitis caused by this fungus are presented. Three small isoquinoline alkaloids inhibited the growth of this rare fungus in vitro, providing a starting point for the application of natural products to treat this highly fatal fungal infection. Our case presentation confirms Apiotrichum mycotoxinivorans as a potential emerging pathogen in patients with hematological malignancy undergoing chemotherapy.
由于 Apiotrichum mycotoxinivorans 引起的真菌感染在临床上较为罕见。在此，我们报告了一例患有 B 细胞急性淋巴细胞白血病的女孩发生侵袭性血液和脑脊液感染 Apiotrichum mycotoxinivorans 的病例。这是首次从人类脑脊液中分离出 Apiotrichum mycotoxinivorans。本文介绍了该真菌引起的脑膜炎的 MRI 特征。三种小异喹啉生物碱在体外抑制了这种罕见真菌的生长，为将天然产物应用于治疗这种高致命性真菌感染提供了一个起点。我们的病例报告证实了 Apiotrichum mycotoxinivorans 是接受化疗的血液恶性肿瘤患者中一种潜在的新兴病原体。
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