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特发性全层黄斑孔发病后 4 个月内手术可获得更好的视力结果:来自爱尔兰患者队列的结果。

Surgery for idiopathic full-thickness macular holes within four months of symptom onset yields superior visual outcomes: Results from an Irish patient cohort.

机构信息

Department of Ophthalmology, University Hospital Limerick, Limerick, Ireland.

出版信息

Ir J Med Sci. 2024 Jun;193(3):1665-1670. doi: 10.1007/s11845-023-03592-3. Epub 2023 Dec 19.

Abstract

PURPOSE

To describe the anatomical, visual, and safety results of full-thickness macular hole (FTMH) repair surgery and determine factors influencing outcomes.

PATIENTS AND METHODS

A retrospective chart review was performed on all patients who underwent primary FTMH repair surgery by a single surgeon over a 3-year period. For comparisons, Snellen visual acuity (VA) was converted to logMAR equivalent. Anatomical hole closure, visual improvement, and final VA of ≤ 0.30 logMAR were the primary outcome measures.

RESULTS

Twenty eyes of 19 patients were included. Mean patient age was 69 years (range 55 to 80 years) and 74% were female. Mean minimum linear diameter (MLD) was 440 μm (range 170 μm to 1200 μm). Mean duration of symptoms before surgery was 16 weeks (range 3 to 39 weeks). 100% of eyes achieved successful anatomical FTMH closure. Mean VA improved from 1.03 ± 0.43 logMAR (Snellen 6/60) preoperatively to 0.35 ± 0.22 logMAR (Snellen 6/15) postoperatively (p = 0.0001). Patients with worse preoperative VA gained more vision than those with better preoperative VA (p = 0.01). Eyes operated on within 4 months of symptom onset were more than twice as likely to achieve a postoperative VA of ≤ 0.30 logMAR (Snellen 6/12 or better) compared to eyes with a longer duration of symptoms (p = 0.03).

CONCLUSION

FTMH repair surgery was safe and effective, with outcomes comparing favourably with published international studies. All patients benefited from surgery regardless of symptom duration, presenting VA or FTMH size. However, surgery performed within 4 months of symptom-onset was particularly beneficial, highlighting the need for prompt referral and surgery.

摘要

目的

描述全层黄斑裂孔(FTMH)修复手术的解剖学、视觉和安全性结果,并确定影响结果的因素。

方法

对一位外科医生在 3 年内进行的所有原发性 FTMH 修复手术的患者进行了回顾性图表审查。为了进行比较,Snellen 视力(VA)转换为 logMAR 等效值。解剖学上的孔闭合、视力改善和最终 VA≤0.30 logMAR 是主要的结果衡量标准。

结果

共纳入 19 例患者的 20 只眼。患者平均年龄为 69 岁(55 至 80 岁),74%为女性。平均最小线性直径(MLD)为 440μm(170μm 至 1200μm)。术前平均症状持续时间为 16 周(3 至 39 周)。100%的眼实现了成功的解剖学 FTMH 闭合。平均 VA 从术前的 1.03±0.43 logMAR(Snellen 6/60)提高到术后的 0.35±0.22 logMAR(Snellen 6/15)(p=0.0001)。术前 VA 较差的患者比术前 VA 较好的患者获得了更多的视力(p=0.01)。与症状持续时间较长的眼相比,在症状发作后 4 个月内接受手术的眼获得术后 VA≤0.30 logMAR(Snellen 6/12 或更好)的可能性是其两倍以上(p=0.03)。

结论

FTMH 修复手术是安全有效的,其结果与国际上已发表的研究结果相当。无论症状持续时间、表现 VA 或 FTMH 大小如何,所有患者都从手术中受益。然而,在症状发作后 4 个月内进行的手术尤其有益,这突出了及时转诊和手术的必要性。

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