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人乳来源的 subsp. CCFM1269 通过 GH/IGF 轴通过 PI3K/AKT 途径调节骨形成。

Human breastmilk-derived subsp. CCFM1269 regulates bone formation by the GH/IGF axis through PI3K/AKT pathway.

机构信息

State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu, China.

School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.

出版信息

Gut Microbes. 2024 Jan-Dec;16(1):2290344. doi: 10.1080/19490976.2023.2290344. Epub 2023 Dec 20.

DOI:10.1080/19490976.2023.2290344
PMID:38116652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10761167/
Abstract

subsp. is a prevalent member of the gut microbiota of breastfed infants. In this study, the effects of human breastmilk-derived subsp. CCFM1269 on bone formation in developing BALB/c mice were investigated. Newborn female and male mice were assigned to control group (administered saline), CCFM11269 group (administered subsp. CCFM1269, 1 × 10 CFU/mouse/day) and I5TI group (administered subsp. I5TI, 1 × 10 CFU/mouse/day) from 1-week-old to 3-, 4- and 5-week old. subsp. I5TI served as a negative control in this study. The results demonstrated that subsp. CCFM1269 promoted bone formation in growing mice by modulating the composition of the gut microbiota and metabolites. The expression of genes and proteins in the PI3K/AKT pathway was stimulated by subsp. CCFM1269 through the GH/IGF-1 axis in growing mice. This finding suggests subsp. CCFM1269 may be useful for modulating bone metabolism during growth.

摘要

副干酪乳杆菌亚种是母乳喂养婴儿肠道微生物群的主要成员之一。本研究探讨了来源于人乳的副干酪乳杆菌亚种 CCFM1269 对发育中的 BALB/c 小鼠骨形成的影响。新生雌性和雄性小鼠从 1 周龄开始至 3、4 和 5 周龄时分别被分配到对照组（给予生理盐水）、CCFM11269 组（给予副干酪乳杆菌亚种 CCFM1269，1×10 CFU/只/天）和 I5TI 组（给予副干酪乳杆菌亚种 I5TI，1×10 CFU/只/天）。在本研究中，副干酪乳杆菌亚种 I5TI 作为阴性对照。结果表明，副干酪乳杆菌亚种 CCFM1269 通过调节肠道微生物群和代谢物组成来促进生长中的小鼠骨形成。副干酪乳杆菌亚种 CCFM1269 通过生长中的小鼠 GH/IGF-1 轴刺激 PI3K/AKT 通路的基因和蛋白表达。这一发现表明副干酪乳杆菌亚种 CCFM1269 可能有助于调节生长过程中的骨代谢。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/1bc948542cc2/KGMI_A_2290344_F0012_OC.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/b7ae4352f273/KGMI_A_2290344_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/bc9a821a5f2a/KGMI_A_2290344_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/892ddfa60a12/KGMI_A_2290344_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/23319870c6f7/KGMI_A_2290344_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/f49d157825dd/KGMI_A_2290344_F0009_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/fc75f0b3f5d8/KGMI_A_2290344_F0010_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/9ff6070742c8/KGMI_A_2290344_F0011_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/1bc948542cc2/KGMI_A_2290344_F0012_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/9ab79bc3d4ac/KGMI_A_2290344_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/71e805608882/KGMI_A_2290344_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/c202b522ba2c/KGMI_A_2290344_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/97643c59216d/KGMI_A_2290344_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/b7ae4352f273/KGMI_A_2290344_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/bc9a821a5f2a/KGMI_A_2290344_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/892ddfa60a12/KGMI_A_2290344_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/23319870c6f7/KGMI_A_2290344_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/f49d157825dd/KGMI_A_2290344_F0009_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/fc75f0b3f5d8/KGMI_A_2290344_F0010_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/9ff6070742c8/KGMI_A_2290344_F0011_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a0/10761167/1bc948542cc2/KGMI_A_2290344_F0012_OC.jpg

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2
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3
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4
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