• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

对亨廷顿病皮质纹状体突触丧失和认知的补充性见解。

Complementary insights into corticostriatal synapse loss and cognition in Huntington's disease.

机构信息

UCL Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.

UCL Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK; UK Dementia Research Institute, University College London, London WC1N 3BG, UK.

出版信息

Cell Rep Med. 2023 Dec 19;4(12):101314. doi: 10.1016/j.xcrm.2023.101314.

DOI:10.1016/j.xcrm.2023.101314
PMID:38118416
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10772369/
Abstract

In a recent study, Wilton and colleagues link activation of the classical complement pathway with corticostriatal synapse loss and cognitive decline in Huntington's disease..

摘要

在最近的一项研究中，威尔顿及其同事将经典补体途径的激活与亨廷顿病中的皮质纹状体突触丢失和认知能力下降联系起来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3b/10772369/56b5b4d82e1c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3b/10772369/56b5b4d82e1c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3b/10772369/56b5b4d82e1c/gr1.jpg

相似文献

1
Complementary insights into corticostriatal synapse loss and cognition in Huntington's disease.对亨廷顿病皮质纹状体突触丧失和认知的补充性见解。
Cell Rep Med. 2023 Dec 19;4(12):101314. doi: 10.1016/j.xcrm.2023.101314.
2
Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease.小胶质细胞和补体介导亨廷顿病早期皮质纹状体突触丢失和认知功能障碍。
Nat Med. 2023 Nov;29(11):2866-2884. doi: 10.1038/s41591-023-02566-3. Epub 2023 Oct 9.
3
Single Synapse Indicators of Impaired Glutamate Clearance Derived from Fast iGlu Imaging of Cortical Afferents in the Striatum of Normal and Huntington (Q175) Mice.来源于正常和亨廷顿病（Q175）小鼠纹状体皮质传入纤维的快速 iGlu 成像的谷氨酸清除受损的单突触标志物。
J Neurosci. 2019 May 15;39(20):3970-3982. doi: 10.1523/JNEUROSCI.2865-18.2019. Epub 2019 Feb 28.
4
Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model.增强的储存-操作性钙内流导致亨廷顿舞蹈病小鼠模型纹状体突触丢失。
J Neurosci. 2016 Jan 6;36(1):125-41. doi: 10.1523/JNEUROSCI.1038-15.2016.
5
A role for Kalirin-7 in corticostriatal synaptic dysfunction in Huntington's disease.卡利林-7在亨廷顿舞蹈病皮质纹状体突触功能障碍中的作用。
Hum Mol Genet. 2015 Dec 20;24(25):7265-85. doi: 10.1093/hmg/ddv426. Epub 2015 Oct 12.
6
Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.抑制异常的 GluN3A 表达可挽救亨廷顿病模型中的突触和行为损伤。
Nat Med. 2013 Aug;19(8):1030-8. doi: 10.1038/nm.3246. Epub 2013 Jul 14.
7
Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation.人类亨廷顿舞蹈病突变外显子1转基因小鼠的异常突触可塑性和空间认知受损。
J Neurosci. 2000 Jul 1;20(13):5115-23. doi: 10.1523/JNEUROSCI.20-13-05115.2000.
8
Do Changes in Synaptic Autophagy Underlie the Cognitive Impairments in Huntington's Disease?突触自噬的变化是否是亨廷顿病认知障碍的基础？
J Huntingtons Dis. 2021;10(2):227-238. doi: 10.3233/JHD-200466.
9
Corticostriatal synaptic adaptations in Huntington's disease.亨廷顿舞蹈病中的皮质纹状体突触适应性变化
Curr Opin Neurobiol. 2015 Aug;33:53-62. doi: 10.1016/j.conb.2015.01.020. Epub 2015 Feb 18.
10
Innate immune mechanisms mediate loss of corticostriatal synapses in Huntington's disease.先天性免疫机制介导亨廷顿舞蹈症中皮质纹状体突触的丧失。
Nat Med. 2023 Nov;29(11):2718-2719. doi: 10.1038/s41591-023-02616-w.

引用本文的文献

1
Stage-Specific Serum Proteomic Signatures Reveal Early Biomarkers and Molecular Pathways in Huntington's Disease Progression.阶段特异性血清蛋白质组学特征揭示亨廷顿舞蹈病进展中的早期生物标志物和分子途径。
Cells. 2025 Aug 4;14(15):1195. doi: 10.3390/cells14151195.

本文引用的文献

1
Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease.小胶质细胞和补体介导亨廷顿病早期皮质纹状体突触丢失和认知功能障碍。
Nat Med. 2023 Nov;29(11):2866-2884. doi: 10.1038/s41591-023-02566-3. Epub 2023 Oct 9.
2
Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches.通过分子和组织学方法早期检测zQ175大脑中外显子1亨廷顿蛋白聚集。
Brain Commun. 2023 Jan 20;5(1):fcad010. doi: 10.1093/braincomms/fcad010. eCollection 2023.
3
Cerebrospinal fluid biomarkers for assessing Huntington disease onset and severity.
用于评估亨廷顿病发病和严重程度的脑脊液生物标志物。
Brain Commun. 2022 Nov 25;4(6):fcac309. doi: 10.1093/braincomms/fcac309. eCollection 2022.
4
Fronto-striatal circuits for cognitive flexibility in far from onset Huntington's disease: evidence from the Young Adult Study.额颞叶皮质回路对远未发病的亨廷顿病患者认知灵活性的作用：来自青年研究的证据。
J Neurol Neurosurg Psychiatry. 2021 Feb;92(2):143-149. doi: 10.1136/jnnp-2020-324104. Epub 2020 Oct 31.
5
Biological and clinical characteristics of gene carriers far from predicted onset in the Huntington's disease Young Adult Study (HD-YAS): a cross-sectional analysis.亨廷顿病青年研究（HD-YAS）中基因携带者的生物学和临床特征：一项横断面分析。
Lancet Neurol. 2020 Jun;19(6):502-512. doi: 10.1016/S1474-4422(20)30143-5. Epub 2020 May 26.
6
New insights into the immune functions of complement.补体免疫功能的新见解。
Nat Rev Immunol. 2019 Aug;19(8):503-516. doi: 10.1038/s41577-019-0168-x.
7
Huntington disease.亨廷顿舞蹈病。
Nat Rev Dis Primers. 2015 Apr 23;1:15005. doi: 10.1038/nrdp.2015.5.
8
Indexing disease progression at study entry with individuals at-risk for Huntington disease.在研究开始时对亨廷顿病高危个体进行疾病进展的指标检测。
Am J Med Genet B Neuropsychiatr Genet. 2011 Dec;156B(7):751-63. doi: 10.1002/ajmg.b.31232. Epub 2011 Aug 19.
9
The classical complement cascade mediates CNS synapse elimination.经典补体级联反应介导中枢神经系统突触消除。
Cell. 2007 Dec 14;131(6):1164-78. doi: 10.1016/j.cell.2007.10.036.