School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.
PIQUR Therapeutics, Basel, 4057, Switzerland.
Br J Pharmacol. 2023 Oct;180 Suppl 2:S374-S469. doi: 10.1111/bph.16182.
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16182. Transporters are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors and enzymes. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
《药理学简明指南 2023/24》是该系列两年一次出版物的第六版。《药理学简明指南》以表格形式提供了约 1800 个药物靶点和 6000 多个与约 3900 个配体相互作用的关键特性的简明概述,重点是选择性药理学(在有可用信息时),并链接到药物靶点及其配体的开放获取知识库来源(https://www.guidetopharmacology.org/),该知识库提供了靶点和配体特性的更详细视图。尽管《药理学简明指南》有近 500 页,但与网站上呈现的信息和链接相比,呈现的材料大大减少。它提供了一个永久的、可引用的、时间点记录,将在数据库更新后保留。本部分的全部内容可在以下网址找到:http://onlinelibrary.wiley.com/doi/10.1111/bph.16182. 转运蛋白是指南分为的六个主要药理学靶点之一,其他五个是:G 蛋白偶联受体、离子通道、核激素受体、催化受体和酶。这些内容提供了命名指南和最佳可用药理学工具的摘要信息,以及关键参考文献和进一步阅读建议。《药理学简明指南》的横向格式旨在促进比较 2023 年年中前后相关靶点的材料,取代了 2021/22、2019/20、2017/18、2015/16 和 2013/14 年《药理学简明指南》和之前的《受体和通道指南》中呈现的数据。它是与国际基础和临床药理学联合会(NC-IUPHAR)命名和标准委员会密切合作制作的,因此,在适当情况下,为人类药物靶点提供了官方的 IUPHAR 分类和命名。