Department of Medicine, College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.
Department of Internal Medicine, An-Najah National University Hospital, Nablus, 44839, Palestine.
Antimicrob Resist Infect Control. 2023 Dec 20;12(1):149. doi: 10.1186/s13756-023-01355-4.
Pseudomonas infections are among the most common infections encountered in hospitalized patients, especially those with chronic illnesses or an immunocompromised state. Management of these infections has become challenging due to increased antibiotic resistance. Therefore, this study examines the antibiotic resistance profiles of Pseudomonas spp. and the associated factors among patients admitted to a large tertiary hospital in a developing country.
This retrospective observational chart review study assessed patients admitted to a large tertiary hospital in a developing country with a positive culture growth of Pseudomonas from anybody site. Antibiotic susceptibility of the isolated Pseudomonas and patient characteristics were studied from the start of 2021 to the end of 2022. The study ground consisted of 185 patients.
The study included 185 patients with positive Pseudomonas isolates. Males constituted 54.6% of the sample, while 45.4% were females. The median age of the patients was 53 years. Patient comorbidities and risk factors for Pseudomonas infection and multidrug resistance were assessed. Antibiotic resistance to the Pseudomonas regimens showed the highest resistance to meropenem and ciprofloxacin (23.4%, similarly) among isolates of Pseudomonas aeruginosa. Multidrug resistance (MDR) was found in 108 (58.4%) isolates. The most commonly used antibiotic for treatment was piperacillin-tazobactam, accounting for 33.3% of cases, followed by aminoglycosides at 26.6%.
Pseudomonas aeruginosa isolates were resistant to meropenem and ciprofloxacin. Over half of the isolates were multidrug-resistant, which was worrying. Piperacillin-tazobactam and aminoglycosides were the most often utilized antibiotics, highlighting the significance of susceptibility testing. Implementing antimicrobial stewardship programs and infection control measures can help reduce drug resistance and improve outcomes in Pseudomonas infections.
假单胞菌感染是住院患者中最常见的感染之一，尤其是那些患有慢性疾病或免疫功能低下的患者。由于抗生素耐药性的增加，这些感染的管理变得具有挑战性。因此，本研究检查了发展中国家一家大型三级医院住院患者中假单胞菌的抗生素耐药谱及其相关因素。
这项回顾性观察性图表回顾研究评估了从 2021 年初至 2022 年底在发展中国家一家大型三级医院从任何部位培养出假单胞菌阳性的患者。从开始研究时就对分离出的假单胞菌的抗生素敏感性和患者特征进行了研究。该研究的基础是 185 名患者。
该研究包括 185 名携带阳性假单胞菌分离株的患者。男性占样本的 54.6%，而女性占 45.4%。患者的中位年龄为 53 岁。评估了假单胞菌感染和多重耐药的患者合并症和危险因素。假单胞菌方案的抗生素耐药性显示，铜绿假单胞菌分离株对美罗培南和环丙沙星（同样为 23.4%）的耐药性最高。发现 108 株（58.4%）分离株为多重耐药（MDR）。治疗中最常使用的抗生素是哌拉西林他唑巴坦，占 33.3%，其次是氨基糖苷类抗生素，占 26.6%。
铜绿假单胞菌分离株对美罗培南和环丙沙星耐药。超过一半的分离株为多重耐药，这令人担忧。哌拉西林他唑巴坦和氨基糖苷类抗生素是最常用的抗生素，这凸显了药敏试验的重要性。实施抗菌药物管理计划和感染控制措施有助于降低假单胞菌感染的耐药性并改善其结果。
