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大网膜在腹膜肿瘤局部免疫治疗中的意义。

The significance of the omentum in locoregional immunotherapy for peritoneal carcinomatosis.

机构信息

Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.

Navarra Institute for Health Research (IDISNA), Pamplona, Spain.

出版信息

Oncoimmunology. 2023 Nov 20;12(1):2285106. doi: 10.1080/2162402X.2023.2285106. eCollection 2023.

DOI:10.1080/2162402X.2023.2285106
PMID:38126032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10732655/
Abstract

Our recent research has unveiled the potential of locoregional immunotherapy. Cytokine-armored viral vectors, such as modified vaccinia virus Ankara vector encoding single-chain interleukin-12 (MVA.scIL-12), can target the omentum and elicit a robust tumor-specific immune response, all the while minimizing toxicity.

摘要

我们最近的研究揭示了局部免疫治疗的潜力。细胞因子装甲病毒载体，如编码单链白细胞介素 12（MVA.scIL-12）的改良安卡拉牛痘病毒载体，可以靶向大网膜并引发强烈的肿瘤特异性免疫反应，同时最大限度地减少毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0362/10732655/05672abaf2cd/KONI_A_2285106_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0362/10732655/05672abaf2cd/KONI_A_2285106_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0362/10732655/05672abaf2cd/KONI_A_2285106_F0001_OC.jpg

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1
The significance of the omentum in locoregional immunotherapy for peritoneal carcinomatosis.大网膜在腹膜肿瘤局部免疫治疗中的意义。
Oncoimmunology. 2023 Nov 20;12(1):2285106. doi: 10.1080/2162402X.2023.2285106. eCollection 2023.
2
Intraperitoneal administration of a modified vaccinia virus Ankara confers single-chain interleukin-12 expression to the omentum and achieves immune-mediated efficacy against peritoneal carcinomatosis.腹腔内给予改良安卡拉牛痘病毒可使单链白细胞介素-12 在大网膜表达，并实现对腹膜癌病的免疫介导疗效。
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3
Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis.携带 CD40L 和 CD137L 的改良安卡拉病毒重组体对腹膜癌转移的协同抗肿瘤反应。
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本文引用的文献

1
Intraperitoneal administration of a modified vaccinia virus Ankara confers single-chain interleukin-12 expression to the omentum and achieves immune-mediated efficacy against peritoneal carcinomatosis.腹腔内给予改良安卡拉牛痘病毒可使单链白细胞介素-12 在大网膜表达，并实现对腹膜癌病的免疫介导疗效。
J Immunother Cancer. 2023 Nov;11(11). doi: 10.1136/jitc-2023-006702.
2
Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8 T cells eradicates peritoneal metastases in mouse models.腔内过继转导 IL-12 mRNA 修饰的肿瘤特异性 CD8 T 细胞可消除小鼠模型中的腹膜转移。
Oncoimmunology. 2022 Dec 15;12(1):2147317. doi: 10.1080/2162402X.2022.2147317. eCollection 2023.
3
cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory.
cDC1 在网膜中协调先天和适应性反应，这是 T 细胞启动和记忆所必需的。
Sci Immunol. 2022 Sep 30;7(75):eabq7432. doi: 10.1126/sciimmunol.abq7432.
4
Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis.携带 CD40L 和 CD137L 的改良安卡拉病毒重组体对腹膜癌转移的协同抗肿瘤反应。
Oncoimmunology. 2022 Jul 13;11(1):2098657. doi: 10.1080/2162402X.2022.2098657. eCollection 2022.
5
Phase I Study of Oncolytic Vaccinia Virus GL-ONC1 in Patients with Peritoneal Carcinomatosis.溶瘤痘苗病毒 GL-ONC1 治疗腹膜转移癌的 I 期临床研究。
Clin Cancer Res. 2018 Sep 15;24(18):4388-4398. doi: 10.1158/1078-0432.CCR-18-0244. Epub 2018 May 17.
6
Immunological Functions of the Omentum.大网膜的免疫功能
Trends Immunol. 2017 Jul;38(7):526-536. doi: 10.1016/j.it.2017.03.002. Epub 2017 Jun 1.
7
Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming.放疗的远隔效应通过联合免疫刺激 mAb 增强，且依赖于 CD8 T 细胞和交叉呈递。
Cancer Res. 2016 Oct 15;76(20):5994-6005. doi: 10.1158/0008-5472.CAN-16-0549. Epub 2016 Aug 22.
8
Regional CAR-T cell infusions for peritoneal carcinomatosis are superior to systemic delivery.用于腹膜癌病的局部嵌合抗原受体T细胞输注优于全身给药。
Cancer Gene Ther. 2016 May;23(5):142-8. doi: 10.1038/cgt.2016.14. Epub 2016 Apr 15.
9
Peritoneal carcinomatosis.腹膜癌病。
World J Gastroenterol. 2013 Nov 7;19(41):6979-94. doi: 10.3748/wjg.v19.i41.6979.
10
The omentum.网膜。
World J Gastroenterol. 2000 Apr;6(2):169-176. doi: 10.3748/wjg.v6.i2.169.