Yakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo 186-8650, Japan.
Yakult Honsha European Research Center for Microbiology VOF, Technologiepark 94 bus 3, 9052 Ghent, Belgium.
Nutrients. 2023 Dec 15;15(24):5119. doi: 10.3390/nu15245119.
strain Shirota (LcS) modulates psychological homeostasis via the gut-brain axis. To explore the possible efficacy of LcS for improving daytime performance, we conducted a double-blind, randomized, crossover, placebo-controlled study of 12 healthy office workers with sleep complaints. The participants received fermented milk containing viable LcS (daily intake of 1 × 10 colony-forming units) and non-fermented placebo milk, each for a 4-week period. In the last week of each period, the participants underwent assessments of their subjective mood and measurements of physiological state indicators via an electroencephalogram (EEG) and heart rate variability in the morning and afternoon. The attention score in the afternoon as assessed by the visual analog scale was higher in the LcS intake period than in the placebo intake period ( = 0.041). Theta power on EEG measured at rest or during an auditory oddball task in the afternoon was significantly lower in the LcS period than in the placebo period ( = 0.025 and 0.009, respectively). The change rate of theta power was associated with the change in attention score. Treatment-associated changes were also observed in heart rate and the sympathetic nerve activity index. These results indicate that LcS has possible efficacy for improving daytime performance, supported by observations of the related physiological state indicators.
清酒乳杆菌 Shirota（LcS）通过肠-脑轴调节心理稳态。为了探索 LcS 改善日间表现的可能功效，我们对 12 名有睡眠问题的健康上班族进行了一项双盲、随机、交叉、安慰剂对照研究。参与者接受了含有活菌 LcS（每日摄入 1×10 菌落形成单位）的发酵乳和非发酵安慰剂乳，每种各 4 周。在每个周期的最后一周，参与者通过脑电图（EEG）和心率变异性评估早晨和下午的主观情绪和生理状态指标。下午通过视觉模拟量表评估的注意力评分在 LcS 摄入期间高于安慰剂摄入期间（ = 0.041）。下午在休息或进行听觉Oddball 任务时测量的 EEG 中的θ功率在 LcS 期间显著低于安慰剂期间（分别为 0.025 和 0.009）。θ功率的变化率与注意力评分的变化相关。心率和交感神经活动指数也观察到与治疗相关的变化。这些结果表明，LcS 可能通过观察相关的生理状态指标来提高日间表现。
