School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Department of Medicine-Division of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Cancer Med. 2024 Jan;13(1):e6850. doi: 10.1002/cam4.6850. Epub 2023 Dec 22.
Older cancer survivors often value quality of life (QOL) over survival. Life-space mobility (LSM), defined as the individual's spatial geographic mobility range, is an important QOL indicator in older adults with chronic illnesses; however, this relationship is unexplored in older cancer survivors.
We examined the longitudinal associations and causal relationships between LSM and QOL in 153 older cancer survivors (≥65 years) from the University of Alabama at Birmingham (UAB) Study of Aging. LSM was assessed using the UAB Life-Space Assessment-Composite score (LSA-C), and QOL was assessed by the SF-12 Mental Component Score (MCS12) and Physical Component Score (PCS12) at 0 (study entry), 6, 18, 36, 54, and 72 months. We examined the causal relationship between LSM and QOL using a cross-lagged panel model (CLPM).
The cohort (n = 153) was 76 years old on average and predominantly White (58%), female (58%), and married (55%). Longitudinal analyses found LSM decreased over time (p < 0.0001), and this decrease was associated with decreased QOL (PCS12, p < 0.0001, MCS12, p < 0.0001). In the CLPM causal analysis, lower LSM resulted in worse PCS12 (p < 0.001), but not worse MSC12.
Restricted LSM resulted in worse physical QOL over 72 months in a sample of 153 older cancer survivors. Developing and evaluating interventions to preserve greater LSM could be a promising approach to improving QOL.
老年癌症幸存者通常更看重生活质量（QOL）而非生存。生活空间移动性（LSM）定义为个体的空间地理移动范围，是慢性疾病老年患者重要的生活质量指标；然而，在老年癌症幸存者中，这种关系尚未得到探索。
我们在伯明翰阿拉巴马大学（UAB）衰老研究中，对 153 名年龄≥65 岁的老年癌症幸存者进行了 LSM 与 QOL 的纵向关联和因果关系研究。LSM 使用 UAB 生活空间评估综合评分（LSA-C）进行评估，QOL 使用 SF-12 心理成分评分（MCS12）和生理成分评分（PCS12）在 0（研究开始）、6、18、36、54 和 72 个月进行评估。我们使用交叉滞后面板模型（CLPM）来检验 LSM 和 QOL 之间的因果关系。
该队列（n=153）的平均年龄为 76 岁，主要为白人（58%）、女性（58%）和已婚（55%）。纵向分析发现 LSM 随时间推移而降低（p<0.0001），这种降低与 QOL 降低相关（PCS12，p<0.0001，MCS12，p<0.0001）。在 CLPM 因果分析中，较低的 LSM 导致 PCS12 更差（p<0.001），但对 MCS12 没有影响。
在 153 名老年癌症幸存者样本中，受限的 LSM 导致 72 个月的生理 QOL 更差。制定和评估旨在保持更大 LSM 的干预措施可能是提高 QOL 的一种有前途的方法。
