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加拿大对NKF-ASN工作组关于重新评估种族因素在肾病诊断中纳入情况的建议的评论

A Canadian Commentary on the NKF-ASN Task Force Recommendations on Reassessing the Inclusion of Race in Diagnosing Kidney Disease.

作者信息

Auguste Bourne L, Nadeau-Fredette Annie Claire, Parekh Rulan S, Poyah Penelope S, Perl Jeffrey, Sood Manish M, Tangri Navdeep

机构信息

Department of Medicine, University of Toronto, Toronto, ON, Canada.

Division of Nephrology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

出版信息

Kidney Med. 2023 Nov 15;6(1):100746. doi: 10.1016/j.xkme.2023.100746. eCollection 2024 Jan.

Abstract

In 2021, a committee was commissioned by the Canadian Society of Nephrology to comment on the 2021 National Kidney Foundation-American Society of Nephrology Task Force recommendations on the use of race in glomerular filtration rate estimating equations. The committee met on numerous occasions and agreed on several recommendations. However, the committee did not achieve unanimity, with a minority group disagreeing with the scope of the commentary. As a result, this report presents the viewpoint of the majority members. We endorsed many of the recommendations from the National Kidney Foundation-American Society of Nephrology Task Force, most importantly that race should be removed from the estimated glomerular filtration rate creatinine-based equation. We recommend an immediate implementation of the new Chronic Kidney Disease Epidemiology Collaboration equation (2021), which does not discriminate among any group while maintaining precision. Additionally, we recommend that Canadian laboratories and provincial kidney organizations advocate for increased testing and access to cystatin C because the combination of cystatin C and creatinine in revised equations leads to more precise estimates. Finally, we recommend that future research studies evaluating the implementation of the new equations and changes to screening, diagnosis, and management across provincial health programs be prioritized in Canada.

摘要

2021年,加拿大肾脏病学会委托一个委员会对2021年美国国家肾脏基金会-美国肾脏病学会工作组关于种族在肾小球滤过率估算方程中的应用的建议发表评论。该委员会多次召开会议,并就若干建议达成一致。然而,委员会并未达成一致意见,少数群体不同意评论的范围。因此,本报告呈现的是多数成员的观点。我们赞同美国国家肾脏基金会-美国肾脏病学会工作组的许多建议,最重要的是,应从基于肌酐的估算肾小球滤过率方程中去除种族因素。我们建议立即采用新的慢性肾脏病流行病学合作方程(2021年),该方程在保持精确性的同时,不对任何群体进行区分。此外,我们建议加拿大的实验室和省级肾脏组织倡导增加胱抑素C的检测和获取,因为在修订后的方程中,胱抑素C和肌酐相结合可得出更精确的估算值。最后,我们建议在加拿大优先开展未来的研究,评估新方程的实施情况以及省级卫生项目在筛查、诊断和管理方面的变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/435a/10746381/3de915c80d75/gr1.jpg

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