Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Allergy & Clinical Immunology, Yale School of Medicine, New Haven, CT, United States.
Front Immunol. 2023 Dec 8;14:1324084. doi: 10.3389/fimmu.2023.1324084. eCollection 2023.
Developing effective vaccines against viral infections have significant impacts on development, prosperity and well-being of human populations. Thus, successful vaccines such as smallpox and polio vaccines, have promoted global societal well-being. In contrast, ineffective vaccines may fuel arguments that retard scientific progress. We aim to stimulate a multilevel discussion on how to develop effective vaccines against recent and future pandemics by focusing on acquired immunodeficiency syndrome (AIDS), coronavirus disease (COVID) and other viral infections. We appeal to harnessing recent achievements in this field specifically towards a cure for current pandemics and prevention of the next pandemics. Among these, we propose to apply the HIV DNA in chromatin format - an end product of aborted HIV integration in episomal forms, i.e., the chromatin vaccines (cVacc), to elicit the epigenetic silencing and memory that prevent viral replication and infection.
开发针对病毒感染的有效疫苗对人类的发展、繁荣和福祉具有重大影响。因此，像天花和小儿麻痹症疫苗这样成功的疫苗促进了全球社会的福祉。相比之下，无效的疫苗可能会引发阻碍科学进步的争论。我们的目的是通过关注获得性免疫缺陷综合征（艾滋病）、冠状病毒病（COVID）和其他病毒感染，激发关于如何针对最近和未来的大流行开发有效疫苗的多层次讨论。我们呼吁利用这一领域的最新成果，特别是针对当前大流行的治疗方法和下一次大流行的预防方法。在这些方法中，我们建议应用 HIV DNA 在染色质形式——即 HIV 整合在染色体外形式中的中止产物，即染色质疫苗（cVacc），以引发阻止病毒复制和感染的表观遗传沉默和记忆。
