Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Department of Gastric Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, China.
Front Immunol. 2023 Dec 6;14:1282176. doi: 10.3389/fimmu.2023.1282176. eCollection 2023.
As one of the deadliest cancers of the gastrointestinal tract, there has been limited improvement in long-term survival rates for gastric cancer (GC) in recent decades. The poor prognosis is attributed to difficulties in early detection, minimal opportunity for radical resection and resistance to chemotherapy and radiation. Macrophages are among the most abundant infiltrating immune cells in the GC stroma. These cells engage in crosstalk with cancer cells, adipocytes and other stromal cells to regulate metabolic, inflammatory and immune status, generating an immunosuppressive tumour microenvironment (TME) and ultimately promoting tumour initiation and progression. In this review, we summarise recent advances in our understanding of the origin of macrophages and their types and polarisation in cancer and provide an overview of the role of macrophages in GC carcinogenesis and development and their interaction with the GC immune microenvironment and flora. In addition, we explore the role of macrophages in preclinical and clinical trials on drug resistance and in treatment of GC to assess their potential therapeutic value in this disease.
作为胃肠道最致命的癌症之一，近年来胃癌（GC）的长期生存率仅略有提高。预后不良归因于早期检测困难、根治性切除机会少以及对化疗和放疗的耐药性。巨噬细胞是 GC 基质中最丰富的浸润免疫细胞之一。这些细胞与癌细胞、脂肪细胞和其他基质细胞相互作用，调节代谢、炎症和免疫状态，产生免疫抑制性肿瘤微环境（TME），最终促进肿瘤的发生和发展。在这篇综述中，我们总结了最近对巨噬细胞的起源及其在癌症中的类型和极化的理解的进展，并概述了巨噬细胞在 GC 致癌和发展中的作用及其与 GC 免疫微环境和菌群的相互作用。此外，我们探讨了巨噬细胞在药物耐药性的临床前和临床试验以及 GC 治疗中的作用，以评估它们在这种疾病中的潜在治疗价值。
