帕里申疗法可减轻自然衰老小鼠的心脏衰老。
Parishin treatment alleviates cardiac aging in naturally aged mice.
作者信息
Zhou Shixian, Zhao Xinxiu, Wu Li, Yan Ren, Sun Linlin, Zhang Qin, Gong Caixia, Liu Yang, Xiang Lan, Li Shumin, Wang Peixia, Yang Yichen, Ren Wen, Jiang JingJin, Yang Yunmei
机构信息
Department of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang Province, China.
Key Laboratory of Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang province, China.
出版信息
Heliyon. 2023 Nov 28;9(12):e22970. doi: 10.1016/j.heliyon.2023.e22970. eCollection 2023 Dec.
BACKGROUND
Cardiac aging progressively decreases physiological function and drives chronic/degenerative aging-related heart diseases. Therefore, it is crucial to postpone the aging process of heart and create products that combat aging.
AIMS & METHODS: The objective of this study is to examine the effects of parishin, a phenolic glucoside isolated from traditional Chinese medicine , on anti-aging and its underlying mechanism. To assess the senescent biomarkers, cardiac function, cardiac weight/body weight ratio, cardiac transcriptomic changes, and cardiac histopathological features, heart tissue samples were obtained from young mice (12 weeks), aged mice (19 months) treated with parishin, and aged mice that were not treated.
RESULTS
Parishin treatment improved cardiac function, ameliorated aging-induced cardiac injury, hypertrophy, and fibrosis, decreased cardiac senescence biomarkers p16, p21, and IL-6, and increased the "longevity factor" SIRT1 expression in heart tissue. Furthermore, the transcriptomic analysis demonstrated that parishin treatment alleviated the cardiac aging-related downregulation and and upregulation in the heart tissues. The correlation analysis suggested a strong connection between the anti-aging effect of parishin and its regulation of gut microbiota and metabolism in the aged intestine.
CONCLUSION
The present study demonstrates the protective role and underlying mechanism of parishin against cardiac aging in naturally aged mice.
背景
心脏衰老会逐渐降低生理功能，并引发与慢性/退行性衰老相关的心脏病。因此，延缓心脏衰老过程并开发抗衰老产品至关重要。
目的与方法
本研究的目的是研究从中药中分离出的酚糖苷parishin的抗衰老作用及其潜在机制。为了评估衰老生物标志物、心脏功能、心脏重量/体重比、心脏转录组变化和心脏组织病理学特征，从小鼠（12周龄）、接受parishin治疗的老年小鼠（19个月龄）和未接受治疗的老年小鼠获取心脏组织样本。
结果
parishin治疗改善了心脏功能，减轻了衰老诱导的心脏损伤、肥大和纤维化，降低了心脏衰老生物标志物p16、p21和IL-6，并增加了心脏组织中“长寿因子”SIRT1的表达。此外，转录组分析表明，parishin治疗减轻了心脏组织中与心脏衰老相关的下调和上调。相关性分析表明，parishin的抗衰老作用与其对老年肠道微生物群和代谢的调节之间存在密切联系。
结论
本研究证明了parishin在自然衰老小鼠中对心脏衰老的保护作用及其潜在机制。
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