Department of Gastroenterology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Research Center of Digestive Diseases, Central South University, Changsha, Hunan, China.
Front Cell Infect Microbiol. 2023 Dec 8;13:1282956. doi: 10.3389/fcimb.2023.1282956. eCollection 2023.
() infection is thought to impact various extragastric diseases, including nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease. Meanwhile, the pathogenesis of NAFLD needs further research, and effective treatment for this disease remains elusive. In this mini-review, we enumerate and ponder on the evidence demonstrating an association between infection and NAFLD. Primarily, we delve into high-quality meta-analyses and clinical randomized controlled trials focusing on the association studies between the two. We also discuss clinical studies that present opposite conclusions. In addition, we propose a mechanism through which infection aggravates NAFLD: inflammatory cytokines and adipocytokines, insulin resistance, lipid metabolism, intestinal barrier and microbiota, outer membrane vesicles and -infected cell-extracellular vesicles. This mini-review aims to further explore NAFLD pathogenesis and extragastric disease mechanisms caused by infection.
()感染被认为会影响多种胃部以外的疾病，包括非酒精性脂肪性肝病（NAFLD），这是最常见的慢性肝病。同时，NAFLD 的发病机制需要进一步研究，而这种疾病的有效治疗仍然难以捉摸。在这个小型综述中，我们列举并思考了表明感染与 NAFLD 之间存在关联的证据。首先，我们深入研究了聚焦于两者之间关联研究的高质量荟萃分析和临床随机对照试验。我们还讨论了呈现相反结论的临床研究。此外，我们提出了一种机制，即感染加重 NAFLD：炎症细胞因子和脂肪细胞因子、胰岛素抵抗、脂质代谢、肠道屏障和微生物群、外膜囊泡和感染细胞-细胞外囊泡。本小型综述旨在进一步探讨 NAFLD 的发病机制和感染引起的胃部以外疾病的机制。
