Jinan University, Guangzhou, China.
Shenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen, China.
Front Cell Infect Microbiol. 2023 Dec 8;13:1301915. doi: 10.3389/fcimb.2023.1301915. eCollection 2023.
Gene therapy involves introducing and editing foreign genes in the body to treat and prevent genetic diseases. Adeno-associated virus (AAV) vector has become a widely used tool in gene therapy due to its high safety and transfection efficiency.
This study employs bibliometric analysis to explore the foundation and current state of AAV vector application in gene therapy research. A total of 6,069 publications from 1991 to 2022 were analyzed, retrieved from the Science Citation Index Expanded (SCI-E) within the Web of Science Core Collection (WoSCC) of Clarivate Analytics. Institutions, authors, journals, references, and keywords were analyzed and visualized by using VOSviewer and CiteSpace. The R language and Microsoft Excel 365 were used for statistical analyses.
The global literature on AAV vector and gene therapy exhibited consistent growth, with the United States leading in productivity, contributing 3,868 papers and obtaining the highest H-index. Noteworthy authors like Wilson JM, Samulski RJ, Hauswirth WW, and Mingozzi F were among the top 10 most productive and co-cited authors. The journal "Human Gene Therapy" published the most papers (n = 485) on AAV vector and gene therapy. Current research focuses on "gene editing," "gene structure," "CRISPR," and "AAV gene therapy for specific hereditary diseases."
The application of AAV vector in gene therapy has shown continuous growth, fostering international cooperation among countries and institutions. The intersection of gene editing, gene structure, CRISPR, and AAV gene therapy for specific hereditary diseases and AAV vector represents a prominent and prioritized focus in contemporary gene therapy research. This study provides valuable insights into the trends and characteristics of AAV gene therapy research, facilitating further advancements in the field.
基因治疗涉及在体内引入和编辑外源基因，以治疗和预防遗传疾病。腺相关病毒（AAV）载体由于其高安全性和转染效率，已成为基因治疗中广泛使用的工具。
本研究采用文献计量分析方法，探讨 AAV 载体在基因治疗研究中的基础和现状。共分析了 1991 年至 2022 年来自科睿唯安 Web of Science 核心合集（WoSCC）中的科学引文索引扩展版（SCI-E）的 6069 篇出版物。使用 VOSviewer 和 CiteSpace 对机构、作者、期刊、参考文献和关键词进行分析和可视化。使用 R 语言和 Microsoft Excel 365 进行统计分析。
AAV 载体和基因治疗的全球文献呈持续增长态势，美国在生产力方面处于领先地位，发表了 3868 篇论文，H 指数最高。Wilson JM、Samulski RJ、Hauswirth WW 和 Mingozzi F 等知名作者位列最具生产力和高被引作者前 10 名。发表 AAV 载体和基因治疗相关论文最多的期刊是“Human Gene Therapy”（n = 485）。目前的研究重点是“基因编辑”、“基因结构”、“CRISPR”和“AAV 基因治疗特定遗传性疾病”。
AAV 载体在基因治疗中的应用呈持续增长态势，促进了国家和机构间的国际合作。基因编辑、基因结构、CRISPR 和 AAV 基因治疗特定遗传性疾病与 AAV 载体的交叉是当代基因治疗研究的一个突出和优先重点。本研究为 AAV 基因治疗研究的趋势和特征提供了有价值的见解，有助于该领域的进一步发展。
