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2016-2022 年中国上海百日咳博德特氏菌的分子进化和大环内酯类耐药性增加。

Molecular Evolution and Increasing Macrolide Resistance of Bordetella pertussis, Shanghai, China, 2016-2022.

出版信息

Emerg Infect Dis. 2023 Jan;30(1):29-38. doi: 10.3201/eid3001.221588.

DOI:10.3201/eid3001.221588
PMID:38146984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10756392/
Abstract

Resurgence and spread of macrolide-resistant Bordetella pertussis (MRBP) threaten global public health. We collected 283 B. pertussis isolates during 2016-2022 in Shanghai, China, and conducted 23S rRNA gene A2047G mutation detection, multilocus variable-number tandem-repeat analysis, and virulence genotyping analysis. We performed whole-genome sequencing on representative strains. We detected pertussis primarily in infants (0-1 years of age) before 2020 and older children (>5-10 years of age) after 2020. The major genotypes were ptxP1/prn1/fhaB3/ptxA1/ptxC1/fim2-1/fim3-1 (48.7%) and ptxP3/prn2/fhaB1/ptxA1/ptxC2/fim2-1/fim3-1 (47.7%). MRBP increased remarkably from 2016 (36.4%) to 2022 (97.2%). All MRBPs before 2020 harbored ptxP1, and 51.4% belonged to multilocus variable-number tandem-repeat analysis type (MT) 195, whereas ptxP3-MRBP increased from 0% before 2020 to 66.7% after 2020, and all belonged to MT28. MT28 ptxP3-MRBP emerged only after 2020 and replaced the resident MT195 ptxP1-MRBP, revealing that 2020 was a watershed in the transformation of MRBP.

摘要

百日咳鲍特菌大环内酯耐药株（MRBP）的再现和传播威胁着全球公共卫生。我们收集了 2016 年至 2022 年期间上海的 283 株百日咳鲍特菌分离株，并进行了 23S rRNA 基因 A2047G 突变检测、多位点可变数串联重复分析和毒力基因分型分析。我们对代表性菌株进行了全基因组测序。我们发现，2020 年前，主要感染对象为 0-1 岁婴儿，2020 年后，主要感染对象为 5-10 岁以上儿童。主要基因型为 ptxP1/prn1/fhaB3/ptxA1/ptxC1/fim2-1/fim3-1（48.7%）和 ptxP3/prn2/fhaB1/ptxA1/ptxC2/fim2-1/fim3-1（47.7%）。MRBP 从 2016 年的 36.4%显著增加到 2022 年的 97.2%。2020 年前所有的 MRBP 都携带 ptxP1，其中 51.4%属于多位点可变数串联重复分析型（MT）195，而 ptxP3-MRBP 从 2020 年前的 0%增加到 2020 年后的 66.7%，且均属于 MT28。只有在 2020 年之后才出现 MT28 ptxP3-MRBP，并取代了常驻的 MT195 ptxP1-MRBP，表明 2020 年是 MRBP 转变的一个分水岭。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0c/10756392/58b34bcab507/22-1588-F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0c/10756392/00e493a1f678/22-1588-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0c/10756392/c3783d1fb7a1/22-1588-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0c/10756392/51bb6ac493a0/22-1588-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0c/10756392/a23cc97e8e2f/22-1588-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0c/10756392/58b34bcab507/22-1588-F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0c/10756392/00e493a1f678/22-1588-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0c/10756392/c3783d1fb7a1/22-1588-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0c/10756392/51bb6ac493a0/22-1588-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0c/10756392/a23cc97e8e2f/22-1588-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd0c/10756392/58b34bcab507/22-1588-F5.jpg

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