Emerg Infect Dis. 2024 Jan;30(1):105-115. doi: 10.3201/eid3001.230261.
Despite vaccination programs, pertussis has been poorly controlled, especially among older adults in Australia. This longitudinal, retrospective, observational study aimed to estimate the incidence and risk factors of pertussis among persons ≥50 years of age in Australia in the primary care setting, including those with underlying chronic obstructive pulmonary disease (COPD) or asthma. We used the IQVIA general practitioner electronic medical record database to identify patients ≥50 years of age with a clinical diagnosis of pertussis during 2015-2019. Pertussis incidence rates ranged from 57.6 to 91.4 per 100,000 persons and were higher among women and highest in those 50-64 years of age. Patients with COPD or asthma had higher incidence rates and an increased risk for pertussis compared with the overall population ≥50 years of age. Our findings suggest that persons ≥50 years of age in Australia with COPD or asthma have a higher incidence of and risk for pertussis diagnosis.
尽管有疫苗接种计划，但百日咳仍未得到很好的控制，尤其是在澳大利亚的老年人中。这项纵向、回顾性、观察性研究旨在估计澳大利亚初级保健环境中≥50 岁人群（包括患有潜在慢性阻塞性肺疾病 [COPD] 或哮喘的人群）中百日咳的发病率和危险因素。我们使用 IQVIA 全科医生电子病历数据库，在 2015 年至 2019 年间确定了≥50 岁且临床诊断为百日咳的患者。百日咳发病率在每 100,000 人中 57.6 至 91.4 例之间，女性发病率较高，50-64 岁人群发病率最高。与≥50 岁的整体人群相比，患有 COPD 或哮喘的患者发病率更高，患百日咳的风险也更高。我们的研究结果表明，澳大利亚≥50 岁且患有 COPD 或哮喘的人群中，百日咳的发病率和诊断风险更高。
