CarMeN Laboratory, INSERM 1060-INRAE 1397, Department of Human Nutrition, Lyon Sud Hospital, University of Lyon, Lyon, France.
J Extracell Vesicles. 2024 Jan;13(1):e12382. doi: 10.1002/jev2.12382.
Recent works indicate that the lipid composition of extracellular vesicles (EVs) can modify their biological functions and their incorporation into recipient cells. In particular high-fat diets affect EV biogenesis, EV lipid composition, EV targeting and consequently the cross-talk between tissues. This review connects different research topics to show that a vicious circle is established during the development of high-fat diet-induced obesity, connecting the alteration of lipid metabolism, the composition of extracellular vesicles and the spread of deleterious lipids between tissues, which participates in NAFLD/NASH and diabetes development. According to the studies described in this review, it is urgent to take an interest in this question as the modulation of EV lipid composition could be an important factor to take into account during the therapeutic management of patients suffering from metabolic syndrome and related pathologies such as obesity and diabetes. Furthermore, as lipid modification of EVs is a strategy currently being tested to enable better integration into their target tissue or cell, it is important to consider the impact of these lipid modifications on the homeostasis of these targets.
最近的研究表明，细胞外囊泡 (EVs) 的脂质组成可以改变它们的生物学功能，并将其纳入受体细胞。特别是高脂肪饮食会影响 EV 的生物发生、EV 脂质组成、EV 的靶向性，从而影响组织间的串扰。这篇综述将不同的研究课题联系起来，表明在高脂肪饮食诱导的肥胖发展过程中建立了一个恶性循环，连接了脂质代谢的改变、细胞外囊泡的组成以及有害脂质在组织间的传播，从而参与了非酒精性脂肪性肝病/非酒精性脂肪性肝炎和糖尿病的发展。根据本综述中描述的研究，人们迫切需要关注这个问题，因为 EV 脂质组成的调节可能是治疗代谢综合征及相关疾病（如肥胖和糖尿病）患者时需要考虑的一个重要因素。此外，由于 EV 脂质的修饰是目前正在测试的一种策略，以使其更好地整合到目标组织或细胞中，因此必须考虑这些脂质修饰对这些靶标的内稳态的影响。
