Hubei Key Laboratory of Diabetes and Angiopathy, Hubei University of Science and Technology, Xianning, China.
State Key Laboratory of Trauma, Burns and Combined Injury, College of Preventive Medicine, Army Medical University, Chongqing, China.
Front Immunol. 2023 Dec 13;14:1287130. doi: 10.3389/fimmu.2023.1287130. eCollection 2023.
Evidence from clinical research and animal studies indicates that inflammation is an important factor in the occurrence and development of cardiovascular disease (CVD). Emerging evidence shows that nucleic acids serve as crucial pathogen-associated molecular patterns (PAMPs) or non-infectious damage-associated molecular patterns (DAMPs), are released and then recognized by pattern recognition receptors (PRRs), which activates immunological signaling pathways for host defense. Mechanistically, the released nucleic acids activate cyclic GMP-AMP synthase (cGAS) and its downstream receptor stimulator of interferon genes (STING) to promote type I interferons (IFNs) production, which play an important regulatory function during the initiation of an innate immune response to various diseases, including CVD. This pathway represents an essential defense regulatory mechanism in an organism's innate immune system. In this review, we outline the overall profile of cGAS-STING signaling, summarize the latest findings on nucleic acid release and trafficking, and discuss their potential role in CVD. This review also sheds light on potential directions for future investigations on CVD.
临床研究和动物研究的证据表明，炎症是心血管疾病（CVD）发生和发展的一个重要因素。新出现的证据表明，核酸作为重要的病原体相关分子模式（PAMPs）或非传染性损伤相关分子模式（DAMPs）被释放出来，然后被模式识别受体（PRRs）识别，激活宿主防御的免疫信号通路。从机制上讲，释放的核酸激活环鸟苷酸-腺苷酸合酶（cGAS）及其下游干扰素基因刺激物（STING）受体，促进 I 型干扰素（IFNs）的产生，在对包括 CVD 在内的各种疾病的先天免疫反应的启动中发挥重要的调节作用。该途径代表了机体先天免疫系统中一种重要的防御调节机制。在这篇综述中，我们概述了 cGAS-STING 信号通路的总体概况，总结了关于核酸释放和运输的最新发现，并讨论了它们在 CVD 中的潜在作用。这篇综述还为 CVD 的未来研究提供了潜在的方向。
