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宫颈旁阻滞术后的胎儿心率及子宫活动情况。

Fetal heart rate and uterine activity following paracervical block.

作者信息

Achiron R, Rojansky N, Zakut H

出版信息

Clin Exp Obstet Gynecol. 1987;14(1):52-6.

PMID:3815837
Abstract

Bupivacaine without adrenaline was used for paracervical block (PCB) anesthesia in 60 low-risk parturients in whom there were no signs of fetal asphyxia. In order to evaluate its effects on fetus and uterine activity, 30 patients were given a "high dose" of 50 mg Bupivacaine, an amide-type local anesthetic agent, while 30 patients were given a "low dose" of 25 mg. Continuous fetal heart rate (FHR) monitoring in both study groups revealed nine patients with typically post PCB bradycardia and five patients with moderate PHR depression. All of them were born with excellent Apgar score. Although a decrease in fetal heart rate following PCB was noted in both groups more significant reduction was associated with the high dose block (P less than 0.05). In 11 cases, FHR depression was clearly associated with increased uterine activity, while in another three cases it was not (P less than 0.005). Oxytocin administration during the block did not affect fetal heart rate or uterine activity. The results indicate that FHR depression following PCB using Bupivacaine is dose dependent, transient and not dangerous to a normal fetus. No adverse maternal effects were noted. It is suggested that fetal heart rate depression following PCB using Bupivacaine is related to increased uterine activity.

摘要

对60例无胎儿窒息迹象的低风险产妇,使用不含肾上腺素的布比卡因进行宫颈旁阻滞(PCB)麻醉。为评估其对胎儿和子宫活动的影响,30例患者给予“高剂量”50毫克布比卡因(一种酰胺类局部麻醉剂),30例患者给予“低剂量”25毫克。两个研究组持续监测胎儿心率(FHR)发现,9例患者出现典型的PCB后心动过缓,5例患者胎儿心率中度降低。所有患儿出生时阿氏评分均良好。尽管两组在PCB后均出现胎儿心率下降,但高剂量阻滞时下降更为显著(P<0.05)。11例中,FHR降低与子宫活动增加明显相关,另3例则不然(P<0.005)。阻滞期间使用缩宫素不影响胎儿心率或子宫活动。结果表明,使用布比卡因进行PCB后FHR降低呈剂量依赖性、短暂性,对正常胎儿无危险。未观察到对产妇的不良影响。提示使用布比卡因进行PCB后胎儿心率降低与子宫活动增加有关。

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