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颅咽管瘤的罕见表现:一例创伤后肿瘤内出血导致脑梗死的病例报告。

Uncommon Presentation of Craniopharyngioma: A Case Report of Post-traumatic Intratumoral Hemorrhage Leading to Cerebral Infarct.

作者信息

Hegde Siddhi, Badhe Padma V, Popalghat Trupti, Suthar Pokhraj P, Ansari Shehbaz M

机构信息

Department of Radiology, Father Muller Medical College Hospital, Mangalore, IND.

Department of Radiology, Seth Gordhandas Sunderdas (GS) Medical College and King Edward Memorial (KEM) Hospital, Mumbai, IND.

出版信息

Cureus. 2023 Nov 29;15(11):e49669. doi: 10.7759/cureus.49669. eCollection 2023 Nov.

Abstract

Craniopharyngiomas emanate from squamous cell remnants in the hypophyseal/pharyngeal duct region. This report details the unprecedented case of a 29-year-old male with adamantinomatous craniopharyngioma, who, following a motor vehicle collision (MVC), presented with post-traumatic intratumoral hemorrhage leading to acute basal ganglia infarct. The patient, previously subjected to subtotal resection, exhibited focal neurological deficits attributed to compression of lenticulostriate arteries due to the sudden increase in tumor volume. The patient, ineligible for thrombolysis or thrombectomy, was conservatively managed post-MVC. Subtotal resection occurred four months later. After one year, persistent right-sided weakness (2/5 motor power) remained, and the recommended stereotactic radiotherapy was declined by the patient. Notably, this instance represents the first documented case of post-traumatic intratumoral hemorrhage in adamantinomatous craniopharyngioma. This report distinguishes between adamantinomatous and papillary subtypes, noting their prevalence in different age groups. While these tumors commonly present with gradual vision changes, fatigue, and endocrine dysfunction, complications such as intra-tumoral hemorrhage remain rare. This report serves as an educational tool, shedding light on potential complications and urging increased vigilance in managing craniopharyngiomas.

摘要

颅咽管瘤起源于垂体/咽管区域的鳞状细胞残余物。本报告详细介绍了一例前所未有的病例,一名29岁患有造釉细胞瘤型颅咽管瘤的男性,在机动车碰撞(MVC)后,出现创伤后肿瘤内出血,导致急性基底节梗死。该患者此前接受了次全切除,由于肿瘤体积突然增大,压迫豆纹动脉,出现了局灶性神经功能缺损。该患者不符合溶栓或取栓条件,在MVC后接受了保守治疗。四个月后进行了次全切除。一年后,患者仍持续存在右侧肢体无力(肌力2/5),且患者拒绝了推荐的立体定向放射治疗。值得注意的是,这是造釉细胞瘤型颅咽管瘤创伤后肿瘤内出血的首例文献记载病例。本报告区分了造釉细胞瘤型和乳头型亚型,指出了它们在不同年龄组中的患病率。虽然这些肿瘤通常表现为渐进性视力改变、疲劳和内分泌功能障碍,但肿瘤内出血等并发症仍然罕见。本报告作为一种教育工具,揭示了潜在的并发症,并敦促在颅咽管瘤的管理中提高警惕。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e65/10756656/5b0934c03ce1/cureus-0015-00000049669-i01.jpg

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