Kim Jongwon, So Byeongchan, Heo Yongki, So Hongyun, Jo Jung Ki
Department of Medical and Digital Engineering, Hanyang University, Seoul, Korea.
Institute of Nano Science and Technology, Hanyang University, Seoul, Korea.
World J Mens Health. 2024 Jul;42(3):487-501. doi: 10.5534/wjmh.230118. Epub 2024 Jan 2.
Many contraceptive methods have been developed over the years due to high demand. However, female contraceptive pills and devices do not work for all females due to health conditions and side effects. Also, the number of males who want to actively participate in family planning is gradually increasing. However, the only contraceptive options currently available to males are condoms and vasectomy. Therefore, many male contraceptive methods, including medication (hormonal and non-hormonal therapy) and mechanical methods, are under development. Reversibility, safety, persistence, degree of invasion, promptness, and the suppression of anti-sperm antibody formation are essential factors in the development of male contraceptive methods. In this paper, male contraceptive methods under development are reviewed according to those essential factors. Furthermore, the timeline for the availability of a new male contraception is discussed.
多年来,由于需求旺盛,人们研发出了许多避孕方法。然而,由于健康状况和副作用,女性避孕药和避孕器具并非对所有女性都有效。此外,想要积极参与计划生育的男性数量也在逐渐增加。然而,目前男性可用的避孕方法只有避孕套和输精管切除术。因此,许多男性避孕方法,包括药物治疗(激素和非激素疗法)和机械方法,都在研发中。可逆性、安全性、持久性、侵入程度、及时性以及抗精子抗体形成的抑制是男性避孕方法研发中的关键因素。本文根据这些关键因素对正在研发的男性避孕方法进行了综述。此外,还讨论了新型男性避孕药具上市的时间线。