Department of Evidence-Based Medicine, Southwest Medical University, Luzhou, Sichuan, China.
Department of Rheumatology and Immunology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Front Immunol. 2023 Dec 18;14:1305590. doi: 10.3389/fimmu.2023.1305590. eCollection 2023.
Systemic lupus erythematosus (SLE) is an inflammatory disorder related to immunity dysfunction. The Th1 cell family including Th1 cells, transcription factor T-bet, and related cytokines IFNγ, TNFα, IL-2, IL-18, TGF-β, and IL-12 have been widely discussed in autoimmunity, such as SLE. In this review, we will comprehensively discuss the expression profile of the Th1 cell family in both SLE patients and animal models and clarify how the family members are involved in lupus development. Interestingly, T-bet-related age-associated B cells (ABCs) and low-dose IL-2 treatment in lupus were emergently discussed as well. Collection of the evidence will better understand the roles of the Th1 cell family in lupus pathogenesis, especially targeting IL-2 in lupus.
系统性红斑狼疮（SLE）是一种与免疫功能障碍相关的炎症性疾病。Th1 细胞家族包括 Th1 细胞、转录因子 T 细胞特异性转录因子（T-bet）以及相关细胞因子 IFNγ、TNFα、IL-2、IL-18、TGF-β和 IL-12，它们在自身免疫性疾病，如 SLE 中已被广泛讨论。在这篇综述中，我们将全面讨论 Th1 细胞家族在 SLE 患者和动物模型中的表达谱，并阐明家族成员如何参与狼疮的发生。有趣的是，T-bet 相关的年龄相关 B 细胞（ABCs）和狼疮中的低剂量 IL-2 治疗也在紧急讨论中。收集这些证据将有助于更好地了解 Th1 细胞家族在狼疮发病机制中的作用，特别是针对狼疮中的 IL-2。
