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mRNA 递送至癌症免疫治疗的从基础到临床的途径。

Path towards mRNA delivery for cancer immunotherapy from bench to bedside.

机构信息

Department of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

出版信息

Theranostics. 2024 Jan 1;14(1):96-115. doi: 10.7150/thno.89247. eCollection 2024.

DOI:10.7150/thno.89247
PMID:38164145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10750210/
Abstract

Messenger RNA (mRNA) has emerged as a promising therapeutic agent for the prevention and treatment of various diseases. mRNA vaccines, in particular, offer an alternative approach to conventional vaccines, boasting high potency, rapid development capabilities, cost-effectiveness, and safe administration. However, the clinical application of mRNA vaccines is hindered by the challenges of mRNA instability and inefficient delivery. In recent times, remarkable technological advancements have emerged to address these challenges, utilizing two main approaches: transfection of dendritic cells (DCs) with mRNA and direct injection of mRNA-based therapeutics, either with or without a carrier. This review offers a comprehensive overview of major non-viral vectors employed for mRNA vaccine delivery. It showcases notable preclinical and clinical studies in the field of cancer immunotherapy and discusses important considerations for advancing these promising vaccine platforms for broader therapeutic applications. Additionally, we provide insights into future possibilities and the remaining challenges in mRNA delivery technology, emphasizing the significance of ongoing research in mRNA-based therapeutics.

摘要

信使 RNA（mRNA）已成为预防和治疗各种疾病的有前途的治疗剂。特别是 mRNA 疫苗提供了一种替代传统疫苗的方法，具有高效力、快速开发能力、成本效益和安全管理的特点。然而，mRNA 疫苗的临床应用受到 mRNA 不稳定性和低效递送的挑战的阻碍。最近，出现了一些显著的技术进步，通过两种主要方法来解决这些挑战：用 mRNA 转染树突状细胞（DC）和直接注射基于 mRNA 的治疗药物，无论是否有载体。本综述全面概述了用于 mRNA 疫苗递送的主要非病毒载体。它展示了癌症免疫治疗领域的重要临床前和临床研究，并讨论了为这些有前途的疫苗平台推进更广泛的治疗应用的重要考虑因素。此外，我们还提供了对 mRNA 递送技术未来可能性和剩余挑战的见解，强调了基于 mRNA 的治疗剂的持续研究的重要性。

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