School of Medical Technology, Beijing Institute of Technology, Beijing, China, 100081.
Dept. of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 100084.
Theranostics. 2024 Jan 1;14(1):341-362. doi: 10.7150/thno.87783. eCollection 2024.
Minimally-invasive diagnosis and therapy have gradually become the trend and research hotspot of current medical applications. The integration of intraoperative diagnosis and treatment is a development important direction for real-time detection, minimally-invasive diagnosis and therapy to reduce mortality and improve the quality of life of patients, so called minimally-invasive theranostics (MIT). Light is an important theranostic tool for the treatment of cancerous tissues. Light-mediated minimally-invasive theranostics (LMIT) is a novel evolutionary technology that integrates diagnosis and therapeutics for the less invasive treatment of diseased tissues. Intelligent theranostics would promote precision surgery based on the optical characterization of cancerous tissues. Furthermore, MIT also requires the assistance of smart medical devices or robots. And, optical multimodality lay a solid foundation for intelligent MIT. In this review, we summarize the important state-of-the-arts of optical MIT or LMIT in oncology. Multimodal optical image-guided intelligent treatment is another focus. Intraoperative imaging and real-time analysis-guided optical treatment are also systemically discussed. Finally, the potential challenges and future perspectives of intelligent optical MIT are discussed.
微创诊断和治疗已逐渐成为当前医学应用的趋势和研究热点。术中诊断和治疗的融合是实时检测、微创诊断和治疗的一个重要发展方向，可以降低死亡率并提高患者的生活质量，即微创治疗学（minimally-invasive theranostics，MIT）。光作为癌症组织治疗的重要治疗工具。光介导的微创治疗学（light-mediated minimally-invasive theranostics，LMIT）是一种将诊断和治疗相结合的新型进化技术，用于对病变组织进行微创治疗。智能治疗学将基于癌症组织的光学特性来促进精准手术。此外，MIT 还需要智能医疗设备或机器人的辅助。并且，光学多模态为智能 MIT 奠定了坚实的基础。在这篇综述中，我们总结了肿瘤学中光学 MIT 或 LMIT 的重要最新技术。多模态光学图像引导的智能治疗是另一个重点。我们还系统地讨论了术中成像和实时分析引导的光学治疗。最后，讨论了智能光学 MIT 的潜在挑战和未来展望。
