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敲除 MDA-MB-231 乳腺癌细胞中的 KDM3A 可抑制肿瘤恶性程度并促进细胞凋亡。

Knockout of KDM3A in MDA-MB-231 breast cancer cells inhibits tumor malignancy and promotes apoptosis.

机构信息

The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830000, China.

Imaging Center of the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830000, China.

出版信息

J Mol Histol. 2024 Feb;55(1):139-148. doi: 10.1007/s10735-023-10178-x. Epub 2024 Jan 2.

DOI:10.1007/s10735-023-10178-x
PMID:38165573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10830655/
Abstract

The histone lysine demethylase 3 A (KDM3A) is vital for the regulation of cancer physiology and pathophysiology. The purpose of this study was to investigate the effect of KDM3A expression with triple-negative breast cancer (TNBC) invasion and metastasis. In our results, knockout of KDM3A in TNBC MDA-MB-231 cells promoted apoptosis and inhibited the proliferation, invasion and metastasis of MDA-MB-231 cells. In addition, we found that in vivo experiments indicated that the growth, invasion and metastasis of metastatic neoplasms were significantly inhibited by knockout of KDM3A in a TNBC metastasis model. These findings suggest that KDM3A may be a potential therapeutic target for the treatment and prevention of TNBC, providing a critical theoretical basis for the effective prevention or treatment of breast cancer disease.

摘要

组蛋白赖氨酸去甲基酶 3A（KDM3A）对于癌症生理和病理生理学的调节至关重要。本研究旨在探讨 KDM3A 表达与三阴性乳腺癌（TNBC）侵袭和转移的关系。在我们的研究结果中，TNBC MDA-MB-231 细胞中 KDM3A 的敲除促进了细胞凋亡，并抑制了 MDA-MB-231 细胞的增殖、侵袭和转移。此外，我们发现体内实验表明，在 TNBC 转移模型中敲除 KDM3A 可显著抑制转移瘤的生长、侵袭和转移。这些发现表明，KDM3A 可能是治疗和预防 TNBC 的潜在治疗靶点，为乳腺癌疾病的有效预防或治疗提供了重要的理论基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89b2/10830655/18b0b021aa81/10735_2023_10178_Fig11_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89b2/10830655/224d977ee9e7/10735_2023_10178_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89b2/10830655/18b0b021aa81/10735_2023_10178_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89b2/10830655/fec8abf278df/10735_2023_10178_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89b2/10830655/c778a6e0fadc/10735_2023_10178_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89b2/10830655/0ce7e043ae9a/10735_2023_10178_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89b2/10830655/a94d0f1afe9f/10735_2023_10178_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89b2/10830655/bb419dc16cd1/10735_2023_10178_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89b2/10830655/224d977ee9e7/10735_2023_10178_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89b2/10830655/18b0b021aa81/10735_2023_10178_Fig11_HTML.jpg

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本文引用的文献

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The most likely but largely ignored triggering factor for breast (or all) cancer invasion.乳腺癌（或所有癌症）侵袭最可能但很大程度上被忽视的触发因素。
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Editorial: Quality of Life in Breast Cancer Patients and Survivors.社论：乳腺癌患者及幸存者的生活质量
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