Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan, 31151, Chungcheongnam-do, South Korea.
Department of Nuclear Medicine, Soonchunhyang University Hospital Cheonan, Cheonan, 31151, Chungcheongnam-do, South Korea.
Exp Mol Med. 2024 Feb;56(1):95-99. doi: 10.1038/s12276-023-01148-0. Epub 2024 Jan 4.
Astrocytes are involved in various processes in the central nervous system (CNS). As the most abundant cell type in the CNS, astrocytes play an essential role in neuronal maintenance and support, synaptic activity, neuronal metabolism, and amyloid-beta (Aβ) clearance. Alzheimer's disease (AD) is a neurodegenerative disorder associated with cognitive and behavioral impairment. The transformation of astrocytes is involved in various neurodegenerative diseases, such as AD. Since astrocytes have functional diversity and morphological and physiological heterogeneity in the CNS, AD-related astrocytes might show various pathological phenotypes during AD. Astrocytes developing pathological phenotypes could contribute to AD progression. In this review, we provide an overview of the pathological phenotypes of astrocytes in the context of AD, highlighting recent findings in human and mouse AD.
星形胶质细胞参与中枢神经系统（CNS）的各种过程。作为 CNS 中最丰富的细胞类型，星形胶质细胞在神经元维持和支持、突触活动、神经元代谢和淀粉样蛋白-β（Aβ）清除中发挥着重要作用。阿尔茨海默病（AD）是一种与认知和行为障碍相关的神经退行性疾病。星形胶质细胞的转化涉及各种神经退行性疾病，如 AD。由于星形胶质细胞在 CNS 中具有功能多样性和形态及生理学异质性，AD 相关星形胶质细胞在 AD 期间可能表现出各种病理表型。发生病理表型的星形胶质细胞可能有助于 AD 的进展。在这篇综述中，我们概述了 AD 背景下星形胶质细胞的病理表型，重点介绍了人类和小鼠 AD 的最新发现。
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