He Peikun, Gao Yuyuan, Shi Lin, Li Yanyi, Qiu Yihui, Feng Shujun, Tie Zihui, Gong Liangxu, Ma Guixian, Zhang Yuhu, Nie Kun, Wang Lijuan
School of Medicine, South China University of Technology, Guangzhou, 510006, Guangdong Province, China; Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong Province, China; Guangzhou Key Laboratory of Diagnosis and Treatment for Neurodegenerative Diseases, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong Province, China.
Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong Province, China; Guangzhou Key Laboratory of Diagnosis and Treatment for Neurodegenerative Diseases, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong Province, China.
Parkinsonism Relat Disord. 2024 Mar;120:105987. doi: 10.1016/j.parkreldis.2023.105987. Epub 2023 Dec 31.
This study aims to determine the link between choroid plexus (CP) volume and cognitive decline in patients with early-stage Parkinson's disease (PD) and to test whether pathological proteins in the cerebrospinal fluid (CSF) are involved in the modulation of any detrimental effects from CP volume.
Data on 95 early-stage PD patients with 5 years of follow-up were collected from the Parkinson's Progression Marker Initiative cohort. The patients were separated into three groups based on tertiles of baseline CP volume. We then used a linear mixed model for longitudinal analysis and conducted path analysis to investigate mediating effects.
At baseline, the patients in both the upper and middle tertile group were older and had lower concentrations of CSF Aβ than those in the lowest tertile group. Longitudinal analysis showed that the upper tertile group suffered from a more rapid cognitive decline in the Symbol Digit Modalities test, Hopkins Verbal Learning Test (HVLT)-retention, and HVLT delayed recalled score. Furthermore, path analysis showed that the pathological effects of CP volume on the 5-year decline in memory might be partly mediated by the CSF Aβ/αsyn ratio.
CP enlargement could be an independent risk factor for decreased cognition in patients with early-stage PD, and this risk may be mediated by CSF pathological proteins.
本研究旨在确定早期帕金森病（PD）患者脉络丛（CP）体积与认知衰退之间的联系，并测试脑脊液（CSF）中的病理性蛋白质是否参与调节CP体积产生的任何有害影响。
从帕金森病进展标志物倡议队列中收集了95例有5年随访数据的早期PD患者的数据。根据基线CP体积的三分位数将患者分为三组。然后我们使用线性混合模型进行纵向分析，并进行路径分析以研究中介效应。
在基线时，上三分位数组和中三分位数组的患者比最低三分位数组的患者年龄更大，脑脊液Aβ浓度更低。纵向分析表明，上三分位数组在符号数字模态测试、霍普金斯言语学习测试（HVLT）-记忆保持以及HVLT延迟回忆得分方面认知衰退更快。此外，路径分析表明，CP体积对5年记忆衰退的病理影响可能部分由脑脊液Aβ/α突触核蛋白比率介导。
CP增大可能是早期PD患者认知能力下降的独立危险因素，并且这种风险可能由脑脊液病理性蛋白质介导。
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