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保留神经、保留括约肌的直肠癌手术后的功能结果:患者报告的性功能和排尿功能障碍结局

Functional Results After Nerve-Sparing, Sphincter Preserving Rectal Cancer Surgery: Patient-Reported Outcomes of Sexual and Urinary Dysfunction.

作者信息

Patel Swapnil, Raghavan Sriniket, Garg Vidur, Kazi Mufaddal, Sukumar Vivek, Desouza Ashwin, Saklani Avanish

机构信息

Department of Surgical Oncology, Homi Bhabha Cancer Hospital & MPMMCC, TMC, Varanasi, India.

Colorectal Division, Department of GI & HPB Surgery, TMC, Mumbai, 400012 India.

出版信息

Indian J Surg Oncol. 2023 Dec;14(4):868-875. doi: 10.1007/s13193-023-01794-w. Epub 2023 Jul 7.

Abstract

There is an ongoing unmet need of early identification and discussion regarding the sexual and urinary dysfunction in the peri-operative period to improve the quality of life (QoL), particularly in young rectal cancer survivors. Retrospective analysis of prospectively maintained database was done. Male patients less than 60 years who underwent nerve preserving, sphincter sparing rectal cancer surgery between January 2013 and December 2019, were screened. International Index of Erectile Function (IIEF-5) questionnaire was given to assess erectile dysfunction (ED). Patients were asked questions regarding their sexual and urinary function from the EORTC-QL CRC 38 questionnaire, and responses were recorded. Patients were also asked to report any retrograde ejaculation in post-operative period. Sixty-two patients were included in the study. Fifty-four patients (87.1%) received a diversion stoma. Sixteen patients (29.6%) felt stoma was interfering with their sexual function. Six patients (9.7%) reported retrograde ejaculation. Only 5 patients (8.06%) had moderate to severe ED, and the rest had none to mild ED. On univariate and multivariate analysis, only age predicted the development of clinically significant ED. Ten patients (16.1%) had significantly reduced sexual urges, and 23 patients (37.1%) had significant decrease in sexual satisfaction after surgery. Five patients (8.06%) reported having minor urinary complaints. No patient reported having major complaint pertaining to urinary health. While long-term urinary complaints are infrequent, almost half the patient suffered from erectile dysfunction in some form. There is a weak but significant association of age and ED. Follow-up clinic visits provide an ideal opportunity to counsel patients and provide any medical intervention, when necessary.

摘要

围手术期性和泌尿功能障碍的早期识别与讨论仍存在未满足的需求,以提高生活质量(QoL),尤其是在年轻的直肠癌幸存者中。对前瞻性维护的数据库进行了回顾性分析。筛选了2013年1月至2019年12月期间接受保留神经、保留括约肌的直肠癌手术的60岁以下男性患者。采用国际勃起功能指数(IIEF-5)问卷评估勃起功能障碍(ED)。根据欧洲癌症研究与治疗组织生活质量问卷(EORTC-QL CRC 38)向患者询问有关其性和泌尿功能的问题,并记录回答。还要求患者报告术后是否有逆行射精。62名患者纳入研究。54名患者(87.1%)接受了转流造口术。16名患者(29.6%)感觉造口影响了他们的性功能。6名患者(9.7%)报告有逆行射精。只有5名患者(8.06%)有中度至重度ED,其余患者为无至轻度ED。单因素和多因素分析显示,只有年龄可预测具有临床意义的ED的发生。10名患者(16.1%)性冲动明显减少,23名患者(37.1%)术后性满意度显著下降。5名患者(8.0%)报告有轻微的泌尿系统不适。没有患者报告有与泌尿系统健康相关的严重不适。虽然长期泌尿系统不适并不常见,但几乎一半的患者存在某种形式的勃起功能障碍。年龄与ED之间存在微弱但显著关联。随访门诊为咨询患者并在必要时提供任何医疗干预提供了理想机会。

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