Suppr超能文献

Molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3.

作者信息

Li Fahui, Tai Linhua, Sun Xiaoyu, Lv Zhenyu, Tang Wenqin, Wang Tianxin, Zhao Ziyi, Gong Daohong, Ma Shaohua, Tang Shichen, Gu Quanchang, Zhu Xiaolei, Yu Minling, Liu Xiaohong, Wang Jiangyun

机构信息

Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

School of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.

出版信息

Cell Res. 2024 Apr;34(4):323-326. doi: 10.1038/s41422-023-00914-z. Epub 2024 Jan 9.

Abstract
摘要

相似文献

1
Molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3.
Cell Res. 2024 Apr;34(4):323-326. doi: 10.1038/s41422-023-00914-z. Epub 2024 Jan 9.
3
FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing.
FASEB J. 2018 Jan;32(1):289-303. doi: 10.1096/fj.201700252RR. Epub 2017 Sep 7.
4
Short-chain fatty acids and FFAR2 as suppressors of bone resorption.
Bone. 2019 Aug;125:112-121. doi: 10.1016/j.bone.2019.05.016. Epub 2019 May 14.
6
Effects of free fatty acid receptor-2 (FFAR2)-mediated signaling on the regulation of cellular functions in osteosarcoma cells.
Biochem Biophys Res Commun. 2023 Feb 26;646:56-62. doi: 10.1016/j.bbrc.2023.01.067. Epub 2023 Jan 21.
7
The single-cell atlas of short-chain fatty acid receptors in human and mice hearts.
Front Immunol. 2025 Apr 16;16:1538384. doi: 10.3389/fimmu.2025.1538384. eCollection 2025.
8
Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.
Diabetes. 2012 Feb;61(2):364-71. doi: 10.2337/db11-1019. Epub 2011 Dec 21.
9
Identification of transforming activity of free fatty acid receptor 2 by retroviral expression screening.
Cancer Sci. 2010 Jan;101(1):54-9. doi: 10.1111/j.1349-7006.2009.01348.x. Epub 2009 Sep 4.
10
The short-chain fatty acid receptor, FFA2, contributes to gestational glucose homeostasis.
Am J Physiol Endocrinol Metab. 2015 Nov 15;309(10):E840-51. doi: 10.1152/ajpendo.00171.2015. Epub 2015 Sep 22.

引用本文的文献

1
Allosteric modulation and biased signalling at free fatty acid receptor 2.
Nature. 2025 Jun 18. doi: 10.1038/s41586-025-09186-6.
4
Structural insights into lipid chain-length selectivity and allosteric regulation of FFA2.
Nat Commun. 2025 Mar 26;16(1):2809. doi: 10.1038/s41467-025-57983-4.
5
Interkingdom signaling between gastrointestinal hormones and the gut microbiome.
Gut Microbes. 2025 Dec;17(1):2456592. doi: 10.1080/19490976.2025.2456592. Epub 2025 Jan 24.
6
Advances in cryo-electron microscopy (cryoEM) for structure-based drug discovery.
Expert Opin Drug Discov. 2025 Feb;20(2):163-176. doi: 10.1080/17460441.2025.2450636. Epub 2025 Jan 16.
7
Exploring an Intracellular Allosteric Site of CC-Chemokine Receptor 4 from 3D Models, Probe Simulations, and Mutagenesis.
ACS Pharmacol Transl Sci. 2024 Jul 16;7(8):2516-2526. doi: 10.1021/acsptsci.4c00330. eCollection 2024 Aug 9.
8
G protein-coupled receptors (GPCRs): advances in structures, mechanisms, and drug discovery.
Signal Transduct Target Ther. 2024 Apr 10;9(1):88. doi: 10.1038/s41392-024-01803-6.

本文引用的文献

1
GPCR activation and GRK2 assembly by a biased intracellular agonist.
Nature. 2023 Aug;620(7974):676-681. doi: 10.1038/s41586-023-06395-9. Epub 2023 Aug 2.
2
Conserved class B GPCR activation by a biased intracellular agonist.
Nature. 2023 Sep;621(7979):635-641. doi: 10.1038/s41586-023-06467-w. Epub 2023 Jul 31.
3
Class B1 GPCR activation by an intracellular agonist.
Nature. 2023 Jun;618(7967):1085-1093. doi: 10.1038/s41586-023-06169-3. Epub 2023 Jun 7.
4
Structural basis of odorant recognition by a human odorant receptor.
Nature. 2023 Mar;615(7953):742-749. doi: 10.1038/s41586-023-05798-y. Epub 2023 Mar 15.
5
Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science. 2023 Apr 7;380(6640):eadd6220. doi: 10.1126/science.add6220.
6
AR420626, a selective agonist of GPR41/FFA3, suppresses growth of hepatocellular carcinoma cells by inducing apoptosis HDAC inhibition.
Ther Adv Med Oncol. 2020 Mar 20;12:1758835920913432. doi: 10.1177/1758835920913432. eCollection 2020.
7
The use of consensus sequence information to engineer stability and activity in proteins.
Methods Enzymol. 2020;643:149-179. doi: 10.1016/bs.mie.2020.06.001. Epub 2020 Jul 17.
9
Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-G Complex Structures.
Cell. 2020 Feb 20;180(4):655-665.e18. doi: 10.1016/j.cell.2020.01.008. Epub 2020 Jan 30.
10
Free Fatty Acid Receptors in Health and Disease.
Physiol Rev. 2020 Jan 1;100(1):171-210. doi: 10.1152/physrev.00041.2018. Epub 2019 Sep 5.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验