HK II 在肿瘤发展中的促进作用及其抑制剂的研究进展。
The Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors.
机构信息
Department of Medicinal Chemistry, College of Pharmaceutical Sciences of Capital Medical University, Beijing 100069, China.
Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, Beijing Laboratory of Biomedical Materials, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China.
出版信息
Molecules. 2023 Dec 22;29(1):75. doi: 10.3390/molecules29010075.
Increased glycolysis is a key characteristic of malignant cells that contributes to their high proliferation rates and ability to develop drug resistance. The glycolysis rate-limiting enzyme hexokinase II (HK II) is overexpressed in most tumor cells and significantly affects tumor development. This paper examines the structure of HK II and the specific biological factors that influence its role in tumor development, as well as the potential of HK II inhibitors in antitumor therapy. Furthermore, we identify and discuss the inhibitors of HK II that have been reported in the literature.
糖酵解增加是恶性细胞的一个关键特征，有助于其高增殖率和产生耐药性的能力。糖酵解限速酶己糖激酶 II（HK II）在大多数肿瘤细胞中过度表达，对肿瘤的发展有重要影响。本文研究了 HK II 的结构以及影响其在肿瘤发展中作用的特定生物学因素，以及 HK II 抑制剂在抗肿瘤治疗中的潜力。此外，我们还确定并讨论了文献中报道的 HK II 抑制剂。
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