Omadacycline for the Treatment of Severe Pneumonia Complicated with Guillain-Barre Syndrome.

BACKGROUND

() is a pathogen that is seldom implicated in community-acquired pneumonia and is rarely linked to severe pneumonia. Reports of severe pneumonia accompanied by Guillain-Barre syndrome (GBS) are scarce. Tetracyclines are the preferred therapeutic approach for psittacosis. Omadacycline, a novel tetracycline, demonstrates strong antibacterial efficacy against typical bacteria and atypical pathogens, including . However, its application in the treatment of psittacosis pneumonia remains constrained.

CASE PRESENTATION

A 77-year-old female patient was admitted to the hospital presenting with symptoms of fever, low back pain, and headache. The diagnosis of was established through the utilization of metagenomic next-generation sequencing (mNGS). Initial administration of moxifloxacin, meropenem, piperacillin-tazobactam, and doxycycline proved to be ineffective. Subsequent omadacycline leaded to the successful resolution of fever and dyspnea. However, after the endotracheal tube was removed, the patient experienced a rapid decline in symmetrical limb strength, leading to a diagnosis of GBS based on clinical manifestations, cerebrospinal fluid analysis, and electromyography. Following a 5-day course of immunoglobulin therapy and nutritional nerve treatment, the patient's condition ameliorated, culminating in an uncomplicated discharge.

CONCLUSION

This case provides evidence supporting the potential use of omadacycline as a therapeutic option for the treatment of severe pneumonia. The utilization of mNGS technology is of paramount importance in the prompt identification of uncommon pathogens, including . Nevertheless, the occurrence of GBS should be taken into consideration when pneumonia is accompanied by symmetrical limb weakness. These findings have important implications for the diagnosis, treatment, and management of patients with pneumonia.