ColonGen: an efficient polyp segmentation system for generalization improvement using a new comprehensive dataset.

Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths. While polyp detection is important for diagnosing CRC, high miss rates for polyps have been reported during colonoscopy. Most deep learning methods extract features from images using convolutional neural networks (CNNs). In recent years, vision transformer (ViT) models have been employed for image processing and have been successful in image segmentation. It is possible to improve image processing by using transformer models that can extract spatial location information, and CNNs that are capable of aggregating local information. Despite this, recent research shows limited effectiveness in increasing data diversity and generalization accuracy. This paper investigates the generalization proficiency of polyp image segmentation based on transformer architecture and proposes a novel approach using two different ViT architectures. This allows the model to learn representations from different perspectives, which can then be combined to create a richer feature representation. Additionally, a more universal and comprehensive dataset has been derived from the datasets presented in the related research, which can be used for improving generalizations. We first evaluated the generalization of our proposed model using three distinct training-testing scenarios. Our experimental results demonstrate that our ColonGen-V1 outperforms other state-of-the-art methods in all scenarios. As a next step, we used the comprehensive dataset for improving the performance of the model against in- and out-of-domain data. The results show that our ColonGen-V2 outperforms state-of-the-art studies by 5.1%, 1.3%, and 1.1% in ETIS-Larib, Kvasir-Seg, and CVC-ColonDB datasets, respectively. The inclusive dataset and the model introduced in this paper are available to the public through this link: https://github.com/javadmozaffari/Polyp_segmentation .