Ali Sher, Freire Lucas Gabriel Dionisio, Rezende Vanessa Theodoro, Noman Muhammad, Ullah Sana, Badshah Gul, Afridi Muhammad Siddique, Tonin Fernando Gustavo, de Oliveira Carlos Augusto Fernandes
Department of Food Engineering, Faculty of Animal Science and Food Engineering (FZEA), University of São Paulo (USP), Pirassununga 13635-900, SP, Brazil.
Faculty of Veterinary and Animal Science (FMVZ), University of São Paulo (USP), Pirassununga 13635-900, SP, Brazil.
Foods. 2023 Nov 29;12(23):4314. doi: 10.3390/foods12234314.
In this review, the intricate issue about the occurrence levels of mycotoxins in foods is discussed aiming to underline the main knowledge gaps on the persistence of these toxicants in the food production system. Mycotoxins have been a key challenge to the food industry, economic growth, and consumers' health. Despite a breadth of studies over the past decades, the persistence of mycotoxins in foods remain an overlooked concern that urges exploration. Therefore, we aimed to concisely underline the matter and provide possible biochemical and metabolic details that can be relevant to the food sector and overall public health. We also stress the application of computational modeling, high-throughput omics, and high-resolution imaging approaches, which can provide insights into the structural and physicochemical characteristics and the metabolic activities which occur in a stored cereal grain's embryo and endosperm and their relationship with storage fungi and mycotoxins on a cellular level. In addition, there is a need for extensive collaborative network and funding, which will play a key role in finding effective solutions against the persistence of mycotoxins at the genetic and molecular to metabolic levels in the food system.
在本综述中,讨论了食品中霉菌毒素的存在水平这一复杂问题,旨在强调这些有毒物质在食品生产系统中的持久性方面的主要知识空白。霉菌毒素一直是食品行业、经济增长和消费者健康面临的关键挑战。尽管在过去几十年里进行了广泛的研究,但霉菌毒素在食品中的持久性仍然是一个被忽视的问题,亟待探索。因此,我们旨在简要强调这一问题,并提供可能与食品行业和整体公共卫生相关的生化和代谢细节。我们还强调了计算建模、高通量组学和高分辨率成像方法的应用,这些方法可以在细胞水平上深入了解储存谷物的胚和胚乳中的结构和物理化学特性以及代谢活动,以及它们与储存真菌和霉菌毒素的关系。此外,需要广泛的合作网络和资金,这将在寻找针对食品系统中霉菌毒素从基因和分子到代谢水平的持久性的有效解决方案方面发挥关键作用。