Department of Arbovirus, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Front Cell Infect Microbiol. 2024 Jan 3;13:1291937. doi: 10.3389/fcimb.2023.1291937. eCollection 2023.
The Hedi virus (HEDV) and Wuxiang virus (WUXV) are newly discovered Bunyaviruses transmitted by sandflies. The geographical distribution of isolation of these two viruses continues to expand and it has been reported that WUXV causes neurological symptoms and even death in suckling mice. However, little is known about the prevalence of the two viruses in mammalian infections.
In order to understand the infection status of HEDV and WUXV in humans and animals from regions where the viruses have been isolated, this study used Western blotting to detect the positive rates of HEDV and WUXV IgG antibodies in serum samples from febrile patients, dogs, and chickens in the forementioned regions.
The results showed that of the 29 human serum samples, 17.24% (5/29) tested positive for HEDV, while 68.96% (20/29) were positive for WUXV. In the 31 dog serum samples, 87.10% (27/31) were positive for HEDV and 70.97% (22/31) were positive for WUXV, while in the 36 chicken serum samples, 47.22% (17/36) were positive for HEDV, and 52.78% (19/36) were positive for WUXV.
These findings suggest there are widespread infections of HEDV and WUXV in mammals (dogs, chickens) and humans from the regions where these viruses have been isolated. Moreover, the positive rate of HEDV infections was higher in local animals compared to that measured in human specimens. This is the first seroepidemiological study of these two sandfly-transmitted viruses. The findings of the study have practical implications for vector-borne viral infections and related zoonotic infections in China, as well as providing an important reference for studies on the relationship between sandfly-transmitted viruses and zoonotic infections outside of China.
Hedi 病毒（HEDV）和武乡病毒（WUXV）是新发现的沙蝇传播的 Bunyaviruses。这两种病毒的分离地理分布不断扩大，据报道，WUXV 会导致幼鼠出现神经症状甚至死亡。然而，人们对这两种病毒在哺乳动物感染中的流行情况知之甚少。
为了了解从已分离出这两种病毒的地区的人类和动物中 HEDV 和 WUXV 的感染情况，本研究使用 Western blot 检测了来自上述地区发热患者、狗和鸡的血清样本中 HEDV 和 WUXV IgG 抗体的阳性率。
结果显示，在 29 个人血清样本中，17.24%（5/29）检测到 HEDV 阳性，而 68.96%（20/29）检测到 WUXV 阳性。在 31 个狗血清样本中，87.10%（27/31）检测到 HEDV 阳性，70.97%（22/31）检测到 WUXV 阳性，而在 36 个鸡血清样本中，47.22%（17/36）检测到 HEDV 阳性，52.78%（19/36）检测到 WUXV 阳性。
这些发现表明，在这些病毒已被分离的地区，哺乳动物（狗、鸡）和人类中存在广泛的 HEDV 和 WUXV 感染。此外，与人类标本相比，当地动物的 HEDV 感染阳性率更高。这是对这两种沙蝇传播病毒的首次血清流行病学研究。该研究结果对中国的虫媒病毒感染和相关人畜共患病感染具有实际意义，也为中国以外沙蝇传播病毒与人畜共患病关系的研究提供了重要参考。
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