Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA.
Department of Psychiatry, Massachusetts General Hospital, USA.
Drug Alcohol Depend. 2024 Mar 1;256:111096. doi: 10.1016/j.drugalcdep.2024.111096. Epub 2024 Jan 20.
It is important to identify interventions that reduce harm in youth not motivated to change their cannabis use. This study evaluated how short-duration contingency management (CM) impacts cannabis use attitudes and behavior after abstinence incentives are discontinued among non-treatment seeking youth.
Participants (N=220) were randomized to 4 weeks of abstinence-based CM (CB-Abst; n=126) or monitoring (CB-Mon; n=94). Participants completed self-report and provided biochemical measures of cannabis exposure at baseline, end-of-intervention, and 4-week follow-up. Changes in self-reported cannabis use frequency (days/week; times/week) and biochemically verified creatinine-adjusted 11-nor-9-carboxy-tetrahydrocannabinol concentrations (CN-THCCOOH) were analyzed between groups from baseline to follow-up. In CB-Abst, cannabis use goals at end-of-intervention were described and changes in cannabis use at follow-up were explored by goals and cannabis use disorder (CUD) diagnosis.
There was a group by visit interaction on cannabis use (days: beta=0.93, p=0.005; times: beta=0.71, p<0.001; CN-THCCOOH: beta=0.26, p=0.004), with reductions at follow-up detected only in CB-Abst. Following 4 weeks of abstinence, 68.4% of CB-Abst participants wanted to reduce or abstain from cannabis use following completion of CM. Those in CB-Abst who set end-of-intervention reduction goals and were without CUD had greater decreases in cannabis use frequency at follow-up (Goalstime on days/week: beta=-2.27, p<0.001; CUDtime on times/week: beta=0.48, SE=0.24, t=2.01, p=0.048).
Findings support the utility of brief incentivized abstinence for generating motivation to reduce cannabis use and behavior change even after incentives end. This study supports CM as a potentially viable harm reduction strategy for those not yet ready to quit.
识别那些可以减少青少年因无法改变其大麻使用习惯而遭受伤害的干预措施非常重要。本研究评估了在不接受治疗的青少年停止戒除大麻的奖励后,短期强化管理(CM)如何影响他们对大麻使用的态度和行为。
参与者(N=220)被随机分配到 4 周的基于禁欲的 CM(CB-Abst;n=126)或监测(CB-Mon;n=94)。参与者在基线、干预结束时和 4 周随访时完成自我报告,并提供大麻暴露的生物化学测量。从基线到随访,分析两组间自我报告的大麻使用频率(天/周;次/周)和生物化学验证的肌酐调整的 11-羟基-9-羧基-四氢大麻酚浓度(CN-THCCOOH)的变化。在 CB-Abst 中,描述了干预结束时的大麻使用目标,并通过目标和大麻使用障碍(CUD)诊断探讨了随访时的大麻使用变化。
大麻使用的组间访视交互作用有统计学意义(天数:β=0.93,p=0.005;次数:β=0.71,p<0.001;CN-THCCOOH:β=0.26,p=0.004),仅在 CB-Abst 中检测到随访时的减少。在 4 周的禁欲后,68.4%的 CB-Abst 参与者在完成 CM 后希望减少或戒除大麻。在 CB-Abst 中,那些在干预结束时设定减少目标且没有 CUD 的参与者,在随访时大麻使用频率的下降幅度更大(目标天数/周:β=-2.27,p<0.001;CUD次数/周:β=0.48,SE=0.24,t=2.01,p=0.048)。
研究结果支持简短的激励性禁欲可以产生减少大麻使用和行为改变的动力,即使在激励措施结束后也是如此。本研究支持 CM 作为一种潜在可行的减少伤害策略,适用于那些尚未准备好戒烟的人。