缬氨酸代谢。由3-羟基异丁酸生成糖异生。
Valine metabolism. Gluconeogenesis from 3-hydroxyisobutyrate.
作者信息
Letto J, Brosnan M E, Brosnan J T
出版信息
Biochem J. 1986 Dec 15;240(3):909-12. doi: 10.1042/bj2400909.
Abstract
During valine catabolism in muscle both 2-oxoisovalerate and 3-hydroxyisobutyrate can be released into the circulation. 3-Hydroxyisobutyrate is a good gluconeogenic substrate in isolated cortical tubules and hepatocytes. The maximal rate of gluconeogenesis from 3-hydroxyisobutyrate was greater than from 2-oxoisovalerate. We propose that 3-hydroxyisobutyrate is an inter-organ metabolite by which the gluconeogenic potential of valine, whose catabolism has been initiated in muscle, may be conserved.
摘要
在肌肉中的缬氨酸分解代谢过程中，2-氧代异戊酸和3-羟基异丁酸均可释放到循环系统中。3-羟基异丁酸在离体皮质肾小管和肝细胞中是一种良好的糖异生底物。由3-羟基异丁酸进行糖异生的最大速率高于由2-氧代异戊酸进行糖异生的最大速率。我们提出，3-羟基异丁酸是一种器官间代谢物，通过它，在肌肉中已启动分解代谢的缬氨酸的糖异生潜力得以保留。
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