用胍法辛治疗一名静脉注射丁丙诺啡/纳洛酮滥用患者。
Guanfacine Treatment in a Patient with Intravenous Buprenorphine/Naloxone Misuse.
作者信息
Karabulut Sercan
机构信息
Centre of Alcohol and Substance Addiction Treatment, Ataturk State Hospital, Antalya, Türkiye.
出版信息
Case Rep Psychiatry. 2024 Jan 19;2024:6359691. doi: 10.1155/2024/6359691. eCollection 2024.
Abstract
In this case report, we described a patient admitted with buprenorphine/naloxone (BN) misuse, accompanied by intermittent pregabalin misuse, to self-treat the opioid withdrawal symptoms. We treated the withdrawal symptoms after cessation of BN with guanfacine extended-release (XR). To our knowledge, it has been the first case report describing guanfacine-XR in the treatment of BN misuse. Notably, our patient responded to the treatment with a decrease in withdrawal symptoms without any significant side-effect. Although it is not possible to generalize our findings with a single case report, it might be useful to mark guanfacin-XR as a potential treatment agent for opioid use disorders, including patients with synthetic opioid misuse.
摘要
在本病例报告中，我们描述了一名因滥用丁丙诺啡/纳洛酮（BN）入院的患者，该患者伴有间歇性普瑞巴林滥用，以自我治疗阿片类药物戒断症状。我们在停用BN后，使用缓释胍法辛（XR）治疗戒断症状。据我们所知，这是第一例描述缓释胍法辛治疗BN滥用的病例报告。值得注意的是，我们的患者对治疗有反应，戒断症状减轻，且无任何明显副作用。尽管仅通过一例病例报告无法推广我们的研究结果，但将缓释胍法辛标记为阿片类药物使用障碍（包括合成阿片类药物滥用患者）的潜在治疗药物可能是有用的。
相似文献
1
Guanfacine Treatment in a Patient with Intravenous Buprenorphine/Naloxone Misuse.用胍法辛治疗一名静脉注射丁丙诺啡/纳洛酮滥用患者。
Case Rep Psychiatry. 2024 Jan 19;2024:6359691. doi: 10.1155/2024/6359691. eCollection 2024.
2
Intravenous buprenorphine/naloxone and concomitant oral pregabalin misuse: a case report.静脉注射丁丙诺啡/纳洛酮与同时口服普瑞巴林滥用：一例报告
Neuropsychiatr Dis Treat. 2018 Nov 9;14:3033-3035. doi: 10.2147/NDT.S179688. eCollection 2018.
3
Efficacy and safety of a monthly buprenorphine depot injection for opioid use disorder: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.每月一次丁丙诺啡储库注射治疗阿片类药物使用障碍的疗效和安全性：一项多中心、随机、双盲、安慰剂对照、3 期临床试验。
Lancet. 2019 Feb 23;393(10173):778-790. doi: 10.1016/S0140-6736(18)32259-1. Epub 2019 Feb 18.
4
A Case Report: Rapid Micro-Induction of Buprenorphine/Naloxone to Administer Buprenorphine Extended-Release in an Adolescent With Severe Opioid Use Disorder.病例报告：快速微量诱导丁丙诺啡/纳洛酮以给予患有严重阿片类药物使用障碍的青少年丁丙诺啡缓释剂。
Am J Addict. 2020 Nov;29(6):531-535. doi: 10.1111/ajad.13050. Epub 2020 Apr 29.
5
Safety and tolerability of the switch from buprenorphine to buprenorphine/naloxone in an Italian addiction treatment centre.从丁丙诺啡转换为丁丙诺啡/纳洛酮在意大利戒毒治疗中心的安全性和耐受性。
Clin Drug Investig. 2010;30 Suppl 1:27-31. doi: 10.2165/11536030-000000000-00000.
6
Post-Overdose Extended-Release Buprenorphine Initiation Facilitated by a Partnership Between Emergency Medical Services and an Outpatient Substance Use Disorder Observation Unit.急诊医疗服务与门诊药物使用障碍观察单位合作，促进阿片类药物过量后长效丁丙诺啡的起始治疗。
Subst Use Addctn J. 2024 Oct;45(4):771-776. doi: 10.1177/29767342241249386. Epub 2024 May 12.
7
Diagnosis and Treatment of Presumed Naltrexone-XR-precipitated Opioid Withdrawal in a Patient Chronically Treated With Buprenorphine-XR: A Case Report.丁丙诺啡缓释片长期治疗患者中疑似纳曲酮缓释片诱发的阿片类药物戒断反应的诊断与治疗：一例报告
J Addict Med. 2024;18(6):727-729. doi: 10.1097/ADM.0000000000001342. Epub 2024 Jul 5.
8
Intravenous Misuse of Methadone, Buprenorphine and Buprenorphine-Naloxone in Patients Under Opioid Maintenance Treatment: A Cross-Sectional Multicentre Study.静脉内滥用美沙酮、丁丙诺啡和丁丙诺啡-纳洛酮在接受阿片类药物维持治疗的患者中的横断面多中心研究。
Eur Addict Res. 2019;25(1):10-19. doi: 10.1159/000496112. Epub 2019 Jan 9.
9
Therapeutic switch to buprenorphine/naloxone from buprenorphine alone: clinical experience in an Italian addiction centre.从单纯丁丙诺啡转为丁丙诺啡/纳洛酮治疗：意大利戒毒中心的临床经验。
Clin Drug Investig. 2010;30 Suppl 1:13-9. doi: 10.2165/11536040-000000000-00000.
10
Comparative effectiveness of extended-release naltrexone versus buprenorphine-naloxone for opioid relapse prevention (X:BOT): a multicentre, open-label, randomised controlled trial.长效纳曲酮与丁丙诺啡-纳洛酮预防阿片类药物复发的比较效果（X:BOT）：一项多中心、开放标签、随机对照试验。
Lancet. 2018 Jan 27;391(10118):309-318. doi: 10.1016/S0140-6736(17)32812-X. Epub 2017 Nov 14.
本文引用的文献
1
Evaluating Guanfacine Hydrochloride in the Treatment of Attention Deficit Hyperactivity Disorder (ADHD) in Adult Patients: Design, Development and Place in Therapy.评估盐酸胍法辛在成年注意缺陷多动障碍（ADHD）患者中的治疗作用：设计、研发及治疗中的定位。
Drug Des Devel Ther. 2021 May 11;15:1965-1969. doi: 10.2147/DDDT.S221126. eCollection 2021.
2
Diagnosis and Management of Opioid Use Disorder in Hospitalized Patients.住院患者阿片类药物使用障碍的诊断与管理。
Med Clin North Am. 2020 Jul;104(4):695-708. doi: 10.1016/j.mcna.2020.03.003. Epub 2020 May 12.
3
Comparative Effectiveness of Different Treatment Pathways for Opioid Use Disorder.不同阿片类药物使用障碍治疗途径的疗效比较。
JAMA Netw Open. 2020 Feb 5;3(2):e1920622. doi: 10.1001/jamanetworkopen.2019.20622.
4
Lofexidine versus clonidine for mitigation of opioid withdrawal symptoms: A systematic review.洛非西定与可乐定减轻阿片类药物戒断症状的比较：一项系统评价。
J Am Pharm Assoc (2003). 2020 Jan-Feb;60(1):145-152. doi: 10.1016/j.japh.2019.10.004. Epub 2019 Nov 29.
5
Guanfacine extended-release for cannabis use disorder: a pilot feasibility trial.胍法辛缓释剂治疗大麻使用障碍的初步可行性试验。
Am J Drug Alcohol Abuse. 2020;46(1):44-48. doi: 10.1080/00952990.2019.1620259. Epub 2019 Jul 24.
6
Intravenous Misuse of Methadone, Buprenorphine and Buprenorphine-Naloxone in Patients Under Opioid Maintenance Treatment: A Cross-Sectional Multicentre Study.静脉内滥用美沙酮、丁丙诺啡和丁丙诺啡-纳洛酮在接受阿片类药物维持治疗的患者中的横断面多中心研究。
Eur Addict Res. 2019;25(1):10-19. doi: 10.1159/000496112. Epub 2019 Jan 9.
7
The Role of Lofexidine in Management of Opioid Withdrawal.洛非西定在阿片类药物戒断管理中的作用。
Pain Ther. 2019 Jun;8(1):67-78. doi: 10.1007/s40122-018-0108-7. Epub 2018 Dec 18.
8
Intravenous buprenorphine/naloxone and concomitant oral pregabalin misuse: a case report.静脉注射丁丙诺啡/纳洛酮与同时口服普瑞巴林滥用：一例报告
Neuropsychiatr Dis Treat. 2018 Nov 9;14:3033-3035. doi: 10.2147/NDT.S179688. eCollection 2018.
9
Guanfacine decreases symptoms of cannabis withdrawal in daily cannabis smokers.胍法辛可减轻每日吸食大麻者大麻戒断症状。
Addict Biol. 2019 Jul;24(4):707-716. doi: 10.1111/adb.12621. Epub 2018 Apr 16.
10
Abuse liability of intravenous buprenorphine vs. buprenorphine/naloxone: Importance of absolute naloxone amount.静脉注射丁丙诺啡与丁丙诺啡/纳洛酮的滥用可能性：绝对纳洛酮剂量的重要性。
Drug Alcohol Depend. 2017 Oct 1;179:362-369. doi: 10.1016/j.drugalcdep.2017.06.033. Epub 2017 Jul 26.
Zotero 插件