Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110000, Liaoning PR China.
Departments of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 39 Huaxiang Road, Tiexi District, Shenyang 110000, Liaoning PR China.
J Agric Food Chem. 2024 Feb 7;72(5):2411-2433. doi: 10.1021/acs.jafc.3c07536. Epub 2024 Jan 29.
As an important signaling pathway in multicellular eukaryotes, the Wnt signaling pathway participates in a variety of physiological processes. Recent studies have confirmed that the Wnt signaling pathway plays an important role in neurological disorders such as stroke, Alzheimer's disease, and Parkinson's disease. The regulation of Wnt signaling by natural compounds in herbal medicines and nutraceuticals has emerged as a potential strategy for the development of new drugs for neurological disorders. : The aim of this review is to evaluate the latest research results on the efficacy of natural compounds derived from herbs and nutraceuticals in the prevention and treatment of neurological disorders by regulating the Wnt pathway and . A manual and electronic search was performed for English articles available from PubMed, Web of Science, and ScienceDirect from the January 2010 to February 2023. Keywords used for the search engines were "natural products,″ "plant derived products,″ "Wnt+ clinical trials,″ and "Wnt+,″ and/or paired with "natural products″/″plant derived products", and "neurological disorders." A total of 22 articles were enrolled in this review, and a variety of natural compounds from herbal medicine and nutritional foods have been shown to exert therapeutic effects on neurological disorders through the Wnt pathway, including curcumin, resveratrol, and querctrin, etc. These natural products possess antioxidant, anti-inflammatory, and angiogenic properties, confer neurovascular unit and blood-brain barrier integrity protection, and affect neural stem cell differentiation, synaptic formation, and neurogenesis, to play a therapeutic role in neurological disorders. In various and studies and clinical trials, these natural compounds have been shown to be safe and tolerable with few adverse effects. Natural compounds may serve a therapeutic role in neurological disorders by regulating the Wnt pathway. This summary of the research progress of natural compounds targeting the Wnt pathway may provide new insights for the treatment of neurological disorders and potential targets for the development of new drugs.
作为真核多细胞生物中的一个重要信号通路，Wnt 信号通路参与了多种生理过程。最近的研究证实，Wnt 信号通路在中风、阿尔茨海默病和帕金森病等神经退行性疾病中发挥着重要作用。草药和营养保健品中的天然化合物对 Wnt 信号的调节已成为开发神经退行性疾病新药的潜在策略。本文的目的是评估从草药和营养保健品中提取的天然化合物通过调节 Wnt 通路在预防和治疗神经退行性疾病方面的最新研究结果。通过手工和电子检索，从 2010 年 1 月至 2023 年 2 月，从 PubMed、Web of Science 和 ScienceDirect 中获取了英文文章。用于搜索引擎的关键词是“天然产物”、“植物源性产品”、“Wnt+临床试验”和“Wnt+”，并与“天然产物”/“植物源性产品”配对，以及“神经退行性疾病”。本综述共纳入 22 篇文章，表明草药和营养食品中的多种天然化合物通过 Wnt 通路对神经退行性疾病发挥治疗作用，包括姜黄素、白藜芦醇、槲皮素等。这些天然产物具有抗氧化、抗炎和血管生成特性，保护神经血管单元和血脑屏障的完整性，影响神经干细胞分化、突触形成和神经发生，从而在神经退行性疾病中发挥治疗作用。在各种动物和临床试验中，这些天然化合物被证明是安全和耐受的，副作用很少。天然化合物可能通过调节 Wnt 通路在神经退行性疾病中发挥治疗作用。本文总结了针对 Wnt 通路的天然化合物的研究进展，为治疗神经退行性疾病提供了新的思路，并为新药的开发提供了潜在的靶点。
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