Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
JAMA Netw Open. 2024 Jan 2;7(1):e2353877. doi: 10.1001/jamanetworkopen.2023.53877.
Numerous studies have documented the association of self-rated health (SRH) with chronic diseases. However, few studies have investigated its association with semen quality.
To examine the association of SRH with semen quality among men undergoing assisted reproductive technology (ART) in China.
DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study recruited male partners in couples undergoing ART treatment at the Center for Reproductive Medicine, Tongji Hospital, Wuhan, China. A total of 1262 men underwent 2 semen examinations and completed a questionnaire on SRH between December 2018 and January 2020. Data analysis was performed from November 20, 2022, to March 24, 2023.
SRH, including overall physical and mental health, as well as reproductive-related physical and mental health specifically, were reported at baseline recruitment.
Sperm concentration, sperm progressive motility, sperm motility, and sperm count as semen quality parameters.
The study included 1262 men with a mean (SD) age of 32.79 (5.25) years and body mass index of 24.37 (3.68). Men with poorer SRH had lower semen quality (eg, sperm concentration among poor vs very good overall physical health: percentage variation, -14.67%; 95% CI, -23.62% to -4.66%). Among 4 components of SRH, a greater reduction in semen quality was estimated for reproductive-related SRH compared with overall SRH, whereas the greatest reduction was observed for reproductive-related physical SRH. In comparison with men with very good reproductive-related physical SRH, men with poor reproductive-related physical SRH had differences of -24.78% (95% CI, -32.71% to -15.93%) and -25.61% (95% CI, -33.95% to -16.22%) in sperm count and concentration, respectively, and regression coefficients of -9.38 (95% CI, -12.01 to -6.76) and -9.24 (95% CI, -11.82 to -6.66) for sperm motility and sperm progressive motility, respectively.
In this cross-sectional study of Chinese men, poorer SRH was associated with lower semen quality, and reproductive-related physical SRH was the most pronounced indicator. Our findings suggest that SRH, especially reproductive-related physical SRH, was a good indicator of semen quality, which should inform public and clinical regulatory decisions.
许多研究已经记录了自评健康（SRH）与慢性疾病之间的关联。然而，很少有研究调查其与精液质量之间的关系。
研究中国接受辅助生殖技术（ART）的男性中，SRH 与精液质量之间的关系。
设计、地点和参与者：这是一项横断面研究，招募了在中国生殖医学中心接受 ART 治疗的夫妇中的男性伴侣。共有 1262 名男性在 2018 年 12 月至 2020 年 1 月期间进行了 2 次精液检查，并在基线招募时完成了一份关于 SRH 的问卷。数据分析于 2023 年 3 月 24 日从 2022 年 11 月 20 日开始进行。
SRH 包括总体身心健康，以及特定的生殖相关身心健康，在基线招募时报告。
精子浓度、精子前向运动、精子运动和精子计数作为精液质量参数。
研究纳入了 1262 名年龄为 32.79（5.25）岁、体重指数为 24.37（3.68）的男性。SRH 较差的男性精液质量较低（例如，整体身体健康状况较差与非常好之间的精子浓度差异：-14.67%；95%置信区间：-23.62%至-4.66%）。在 4 个 SRH 组成部分中，与总体 SRH 相比，生殖相关 SRH 的精液质量下降幅度更大，而生殖相关身体 SRH 的下降幅度最大。与生殖相关身体 SRH 非常好的男性相比，生殖相关身体 SRH 较差的男性的精子计数和浓度分别降低了-24.78%（95%置信区间：-32.71%至-15.93%）和-25.61%（95%置信区间：-33.95%至-16.22%），精子运动和精子前向运动的回归系数分别为-9.38（95%置信区间：-12.01 至-6.76）和-9.24（95%置信区间：-11.82 至-6.66）。
在这项中国男性的横断面研究中，较差的 SRH 与较低的精液质量相关，而生殖相关的身体 SRH 是最明显的指标。我们的发现表明，SRH，尤其是生殖相关的身体 SRH，是精液质量的一个很好的指标，这应该为公共和临床监管决策提供信息。
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